Edgeworin

CAS# 120028-43-5

Edgeworin

Catalog No. BCN6561----Order now to get a substantial discount!

Product Name & Size Price Stock
Edgeworin: 5mg $748 In Stock
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Quality Control of Edgeworin

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Chemical structure

Edgeworin

3D structure

Chemical Properties of Edgeworin

Cas No. 120028-43-5 SDF Download SDF
PubChem ID 10925304 Appearance White powder
Formula C18H10O6 M.Wt 322.3
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-hydroxy-3-(2-oxochromen-7-yl)oxychromen-2-one
SMILES C1=CC(=CC2=C1C=CC(=O)O2)OC3=CC4=C(C=C(C=C4)O)OC3=O
Standard InChIKey WNLKKLCKMRDNHF-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H10O6/c19-12-4-1-11-7-16(18(21)24-14(11)8-12)22-13-5-2-10-3-6-17(20)23-15(10)9-13/h1-9,19H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Edgeworin

The root and stem of Edgeworthia chrysantha LINDL.

Biological Activity of Edgeworin

Description1. Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA repair synthesis.
TargetsDNA/RNA Synthesis

Edgeworin Dilution Calculator

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Edgeworin Molarity Calculator

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Preparing Stock Solutions of Edgeworin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1027 mL 15.5135 mL 31.027 mL 62.054 mL 77.5675 mL
5 mM 0.6205 mL 3.1027 mL 6.2054 mL 12.4108 mL 15.5135 mL
10 mM 0.3103 mL 1.5513 mL 3.1027 mL 6.2054 mL 7.7567 mL
50 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.2411 mL 1.5513 mL
100 mM 0.031 mL 0.1551 mL 0.3103 mL 0.6205 mL 0.7757 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Edgeworin

Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.[Pubmed:15305045]

Biol Pharm Bull. 2004 Aug;27(8):1312-6.

The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, casegravol, cis-casegravol, and Edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora. The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.

Inhibitors of DNA polymerase beta: activity and mechanism.[Pubmed:18343122]

Bioorg Med Chem. 2008 Apr 15;16(8):4331-40.

Bioassay-guided fractionation of extracts prepared from Couepia polyandra and Edgeworthia gardneri resulted in the isolation of the DNA polymerase beta (pol beta) inhibitors oleanolic acid (1), Edgeworin (2), betulinic acid (3), and stigmasterol (4). Study of these pol beta inhibitors revealed that three of them inhibited both the lyase and polymerase activities of DNA polymerase beta, while stigmasterol inhibited only the lyase activity. Further investigation indicated that the four inhibitors had substantially different effects on the DNA-pol beta binary complex that is believed to be an obligatory intermediate in the lyase reaction. It was found that the inhibitors potentiated the inhibitory action of the anticancer drug bleomycin in cultured A549 cells, without any influence on the expression of pol beta in the cells. The results of the unscheduled DNA synthesis assay support the thesis that the potentiation of bleomycin cytotoxicity by DNA pol beta inhibitors was a result of an inhibition of DNA repair synthesis.

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