Vasicine

CAS# 6159-55-3

Vasicine

Catalog No. BCN4140----Order now to get a substantial discount!

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Vasicine: 5mg $374 In Stock
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Chemical structure

Vasicine

3D structure

Chemical Properties of Vasicine

Cas No. 6159-55-3 SDF Download SDF
PubChem ID 442929 Appearance Powder
Formula C11H12N2O M.Wt 188.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility DMSO : 83.33 mg/mL (442.70 mM; Need ultrasonic)
Chemical Name (3R)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
SMILES C1CN2CC3=CC=CC=C3N=C2C1O
Standard InChIKey YIICVSCAKJMMDJ-SNVBAGLBSA-N
Standard InChI InChI=1S/C11H12N2O/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13/h1-4,10,14H,5-7H2/t10-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Vasicine

The leaves of Adhatoda vasica

Biological Activity of Vasicine

Description1. Vasicine is oxytocic and abortifacient agents. 2. Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. 3. Vasicine can regulate the inflammatory reaction, have great potentials to develop safe medications for respiratory and reproductive medicine.
TargetsAntifection | AChR

Vasicine Dilution Calculator

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Vasicine Molarity Calculator

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Preparing Stock Solutions of Vasicine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.3135 mL 26.5675 mL 53.135 mL 106.2699 mL 132.8374 mL
5 mM 1.0627 mL 5.3135 mL 10.627 mL 21.254 mL 26.5675 mL
10 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
50 mM 0.1063 mL 0.5313 mL 1.0627 mL 2.1254 mL 2.6567 mL
100 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Vasicine

In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor.[Pubmed:25849329]

PLoS One. 2015 Apr 7;10(4):e0122366.

Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease. This study systematically investigated the in vitro and in vivo metabolism of VAS in rat using ultra performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. A total of 72 metabolites were found based on a detailed analysis of their 1H- NMR and 13C NMR data. Six key metabolites were isolated from rat urine and elucidated as vasicinone, vasicinol, vasicinolone, 1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-yl hydrogen sulfate, 9-oxo-1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-yl hydrogen sulfate, and 1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-beta-D-glucuronide. The metabolic pathway of VAS in vivo and in vitro mainly involved monohydroxylation, dihydroxylation, trihydroxylation, oxidation, desaturation, sulfation, and glucuronidation. The main metabolic soft spots in the chemical structure of VAS were the 3-hydroxyl group and the C-9 site. All 72 metabolites were found in the urine sample, and 15, 25, 45, 18, and 11 metabolites were identified from rat feces, plasma, bile, rat liver microsomes, and rat primary hepatocyte incubations, respectively. Results indicated that renal clearance was the major excretion pathway of VAS. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of VAS and its main metabolites were also evaluated. The results indicated that although most metabolites maintained potential inhibitory activity against AChE and BChE, but weaker than that of VAS. VAS undergoes metabolic inactivation process in vivo in respect to cholinesterase inhibitory activity.

Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees.[Pubmed:22713956]

Pak J Pharm Sci. 2012 Jul;25(3):651-6.

Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques. Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 +/- 1.2% and 37.4 +/- 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compound (1) exhibited significant DPPH inhibition activity (70.4 +/- 1.3%, IC(50) = 212.3 +/- 1.9 muM). A dose dependant behavior of Vasicine (1), was indicated in the FRAP assay. Antibacterial activity was checked according to agar well diffusion assay and results revealed that Vasicine (1) showed moderate activity.

Description

Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.

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