DHBP dibromideCAS# 6159-05-3 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 6159-05-3 | SDF | Download SDF |
| PubChem ID | 80262 | Appearance | Powder |
| Formula | C24H38Br2N2 | M.Wt | 514.39 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : 100 mg/mL (194.41 mM; Need ultrasonic) DMSO : ≥ 30 mg/mL (58.32 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 1-heptyl-4-(1-heptylpyridin-1-ium-4-yl)pyridin-1-ium;dibromide | ||
| SMILES | CCCCCCC[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCC.[Br-].[Br-] | ||
| Standard InChIKey | VRXAJMCFEOESJO-UHFFFAOYSA-L | ||
| Standard InChI | InChI=1S/C24H38N2.2BrH/c1-3-5-7-9-11-17-25-19-13-23(14-20-25)24-15-21-26(22-16-24)18-12-10-8-6-4-2;;/h13-16,19-22H,3-12,17-18H2,1-2H3;2*1H/q+2;;/p-2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Blocks calcium release from sarcoplasmic reticulum by direct interaction with the ryanodine receptor. |
DHBP dibromide Dilution Calculator
DHBP dibromide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9441 mL | 9.7203 mL | 19.4405 mL | 38.881 mL | 48.6013 mL |
| 5 mM | 0.3888 mL | 1.9441 mL | 3.8881 mL | 7.7762 mL | 9.7203 mL |
| 10 mM | 0.1944 mL | 0.972 mL | 1.9441 mL | 3.8881 mL | 4.8601 mL |
| 50 mM | 0.0389 mL | 0.1944 mL | 0.3888 mL | 0.7776 mL | 0.972 mL |
| 100 mM | 0.0194 mL | 0.0972 mL | 0.1944 mL | 0.3888 mL | 0.486 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle.[Pubmed:7952884]
Br J Pharmacol. 1994 Aug;112(4):1216-22.
1. The effects of 1,1'-diheptyl-4,4'-bipyridinium dibromide (DHBP), a viologen for electrochromic memory display agent, on calcium release and ryanodine binding were studied with triad-rich sarcoplasmic reticulum (SR) vesicles isolated from rabbit skeletal muscle. 2. DHBP inhibited the calcium release induced by 2 mM caffeine and 2 micrograms ml-1 polylysine with an IC50 value of 5 micrograms ml-1 and 4 micrograms ml-1 respectively. 3. DHBP inhibited [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 micrograms ml-1 and 90-100% inhibition at 20-30 micrograms ml-1. 4. Calcium uptake by SR was inhibited in the presence of caffeine and this inhibition was antagonized by concomitant addition of DHBP. 5. The effect of DHBP on muscle twitches was studied on the mouse diaphragm. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 microM ryanodine were blocked by pretreatment with DHBP. 6. Data from this study provided evidence that DHBP blocked the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor. A possible use of this agent as a specific inhibitor for calcium release and as a muscle relaxant was suggested.
DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
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