Ellagic acid

1 Aleurites sp. 2 Arctostaphylos sp. 3 Bridelia sp. 4 Canarium sp. 5 Castanea sp. 6 Casuarina sp. 7 Cochlospermum sp. 8 Cornus sp. 9 Cyamopsis sp. 10 Dendranthema sp. 11 Eucalyptus sp. 12 Euphorbia sp. 13 Filipendula sp. 14 Flueggea sp. 15 Geranium sp. 16 Haematoxylum sp. 17 Hippophae sp. 18 Liquidambar sp. 19 Lithospermum sp. 20 Lycopus sp. 21 Myrtus sp. 22 Phyllanthus sp. 23 Potentilla sp. 24 Punica sp. 25 Quillaja sp. 26 Ricinus sp. 27 Sanguisorba sp. 28 Sapium sp. 29 Shorea sp. 30 Syzygium sp. 31 Terminalia sp. 32 Tilia sp.

Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC₅₀ values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk?and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutat

Effect of ellagic acid on some haematological, immunological and antioxidant parameters of rainbow trout (Oncorhynchus mykiss).[Pubmed:24401136]

J Anim Physiol Anim Nutr (Berl). 2014 Oct;98(5):936-41.

In this study, effect of Ellagic acid on some haematological, immunological and antioxidant parameters in the blood and various tissues of rainbow trout (Oncorhynchus mykiss) were examined. Four groups of rainbow trout were fed experimental diets containing either no Ellagic acid (control) or supplemented with Ellagic acid at 50 mg/kg diet (EA-50), 100 mg/kg diet (EA-100) or 150 mg/kg diet (EA-150) for 21 days. Samples of the blood and tissue (liver, kidney and spleen) were collected at the end of the experiment and analysed for their haematological profile (the red blood cell count, the haemoglobin concentration and the haematocrit level), immune response (the white blood cell count, the oxidative radical production (NBT activity), the total plasma protein and total immunoglobulin level) and oxidant/antioxidant status (the malondialdehyde level, the superoxide dismutase, catalase and glutathione peroxidase activity as well as the reduced glutathione concentration). The findings of this study demonstrated that Ellagic acid had a positive effect on the haematological parameters, the immune response and the antioxidant enzyme activities of the fish.

Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury.[Pubmed:25637685]

Life Sci. 2015 Mar 1;124:120-7.

AIMS: Traumatic brain injury (TBI) remains one of the main clinical problems globally and is a common cause of death among youth. Cognitive defects such as thinking, memory and behavior or mental health disorders are considered as the most frequent effects of severe and moderate TBI. It has been reported that Ellagic acid (EA), a natural polyphenol, exhibits protective effects against oxidative damage. This study was performed to examine the EA preventive effects on cognitive impairments, long-term potentiation (LTP) deficits in hippocampus and brain inflammation induced by diffuse TBI in rat. MAIN METHODS: Subchronic oral administration of 100 mg/kg EA, 7 consecutive days before induction of trauma (once daily) was used to elucidate the EA effects on passive avoidance memory and hippocampal LTP following TBI. To illustrate the possible mechanisms related to the preventive effects of EA on brain function following TBI, brain content of IL-1beta, IL-6 and blood-brain barrier (BBB) permeability were determined. KEY FINDINGS: EA pretreatment significantly (P<0.001) prevented TBI-induced memory and hippocampal LTP impairments in rat. Furthermore TBI induced elevation in brain content of IL-1beta, IL-6 and BBB permeability were decreased significantly (P<0.001) due to EA pre-treatment. SIGNIFICANCE: Our findings suggest that EA can prevent cognitive and LTP deficits and also prevent brain inflammation following TBI.

Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism.[Pubmed:24534771]

Int Immunopharmacol. 2014 Apr;19(2):290-9.

There are several hypotheses that explain the process of acute inflammation, including free radical overproduction, pro-inflammatory enzyme activation, and release of pro-inflammatory cytokines. In this study, the protective role of Ellagic acid against carrageenan-induced acute inflammation was assessed. In addition, the immunomodulatory action, the antioxidant effects, and the role of COX-2 and NF-kappaB were also investigated. Inflammation was induced by the injection of 100 mul of 1.5% carrageenan solution. Ellagic acid (10, 25, 50, 100 and 200mg/kg), indomethacin (10 mg/kg), meloxicam (4 mg/kg), and saline, were injected 2h before carrageenan injection. The percentage inhibition in the paw weight was calculated. Paws, MDA, NO, GSH, IL-1beta, TNF-alpha, IL-10 and NF-kappaB mRNA expression were estimated. Formalin fixed hind paws were used for histopathological examination and immunohistochemical staining for COX-2 expression. Ellagic acid, meloxicam and indomethacin reduced paws, edema, MDA and NO formation. In addition, all of them restored the depleted GSH contents in the paws. Ellagic acid, meloxicam and indomethacin reduced NF-kappaB mRNA expression. Ellagic acid ameliorated COX-2 expression; meloxicam inhibited while indomethacin failed. Both Ellagic acid and meloxicam increased IL-10 while indomethacin did not. The docking study revealed a high affinity of Ellagic acid towards COX-2. Ellagic acid exhibited a potent anti-inflammatory effect against carrageenan-induced inflammation. The mechanisms of Ellagic acid induced protection were proved to be due to reduction of NO, MDA, IL-1beta, TNF-alpha, COX-2 and NF-kappaB expression and induction of GSH and IL-10 production.

Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways.[Pubmed:23554011]

Environ Toxicol. 2014 Nov;29(11):1262-74.

To investigate the effects of Ellagic acid on the growth inhibition of TSGH8301 human bladder cancer cells in vitro, cells were incubated with various doses of Ellagic acid for different time periods. The phase-contrast microscope was used for examining and photographing the morphological changes in TSGH8301 cells. Flow cytometric assay was used to measure the percentage of viable cells, cell cycle distribution, apoptotic cells, ROS, mitochondrial membrane potential (DeltaPsim), Ca(2+) , caspase-9 and -3 activities in TSGH8301 cells after exposure to Ellagic acid. Western blotting was used to examine the changes of cell cycle and apoptosis associated proteins levels. Results indicated that Ellagic acid induced morphological changes, decreased the percentage of viable cells through the induction of G0/G1 phase arrest and apoptosis, and also showed that Ellagic acid promoted ROS and Ca(2+) productions and decreased the level of DeltaPsim and promoted activities of caspase-9 and -3. The induction of apoptosis also confirmed by annexin V staining, comet assay, DAPI staining and DNA gel electrophoresis showed that Ellagic acid induced apoptosis and DNA damage in TSGH8301 cells. Western blotting assay showed that Ellagic acid promoted p21, p53 and decreased CDC2 and WEE1 for leading to G0/G1 phase arrest and promoting BAD expression, AIF and Endo G, cytochrome c, caspase-9 and -3 for leading to apoptosis in TSGH8301 cells. On the basis of these observations, we suggest that Ellagic acid induced cytotoxic effects for causing a decrease in the percentage of viable cells via G0/G1 phase arrest and induction of apoptosis in TSGH8301 cells.

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.

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