SamidinCAS# 477-33-8 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 477-33-8 | SDF | Download SDF |
| PubChem ID | 442150 | Appearance | Powder |
| Formula | C21H22O7 | M.Wt | 386.4 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(9R,10R)-10-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-9-yl] 3-methylbut-2-enoate | ||
| SMILES | CC(=CC(=O)OC1C(C2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C)OC(=O)C)C | ||
| Standard InChIKey | FNVCLGWRMXTDSM-WOJBJXKFSA-N | ||
| Standard InChI | InChI=1S/C21H22O7/c1-11(2)10-16(24)27-20-19(25-12(3)22)17-14(28-21(20,4)5)8-6-13-7-9-15(23)26-18(13)17/h6-10,19-20H,1-5H3/t19-,20-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. |
| Targets | p65 | NF-kB | AP-1 | COX | p38MAPK | JNK | TNF-α |
Samidin Dilution Calculator
Samidin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.588 mL | 12.94 mL | 25.8799 mL | 51.7598 mL | 64.6998 mL |
| 5 mM | 0.5176 mL | 2.588 mL | 5.176 mL | 10.352 mL | 12.94 mL |
| 10 mM | 0.2588 mL | 1.294 mL | 2.588 mL | 5.176 mL | 6.47 mL |
| 50 mM | 0.0518 mL | 0.2588 mL | 0.5176 mL | 1.0352 mL | 1.294 mL |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.5176 mL | 0.647 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Fast and improved separation of major coumarins in Ammi visnaga (L.) Lam. by supercritical fluid chromatography.[Pubmed:27514847]
J Sep Sci. 2016 Oct;39(20):4042-4048.
The first supercritical fluid chromatography method for the determination of five major coumarins (dihydroSamidin, visnadin, Samidin, khellin, and visnagin) in Ammi visnaga fruits is described. Their baseline separation was possible in less than 5 min by using a UPC(2) HSS C18 SB column with 1.8 mum particle size and a mobile phase comprising CO2 , methanol, acetonitrile, and diethylamine. The type of stationary phase used was of particular relevance because, except for the selected one, the others did not resolve the two structural isomers dihydroSamidin and visnadin. Method validation confirmed that the procedure is linear (R(2) >/= 0.9996) in a concentration range from 6 to 480 mug/mL, it is accurate (recovery rates: 97.2-103.6%) and precise (intraday deviation Samidin, the individual quantification of which is described for the first time, were present at concentrations below 0.14%.
Anti-inflammatory properties of samidin from Seseli resinosum through suppression of NF-kappaB and AP-1-mediated-genes in LPS-stimulated RAW 264.7 cells.[Pubmed:24988983]
Arch Pharm Res. 2014 Nov;37(11):1496-503.
Seseli is a herb widely used for its anti-inflammation, anti-flatulence and various other healing properties. In the present study, we investigated the effects of Samidin on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The results demonstrated that Samidin significantly inhibited the production of nitric oxide, as well as the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2. The results from an electrophoretic mobility shift assay illustrated that Samidin significantly suppressed NF-kappaB and AP-1 DNA-binding affinity. In addition, both the NF-kappaB subunit p65 and the AP-1-related c-jun were markedly inhibited by Samidin. The time course experiment demonstrated that Samidin showed significant inhibitory effect on p38 and JNK activation. Furthermore, tumor necrosis factor-alpha mRNA level were remarkably down-regulated by Samidin in LPS-stimulated macrophages based on quantitative-real-time polymerase chain reaction. Our results suggested that Samidin has a potential to be developed as a therapeutic agent for various inflammatory diseases.
