IsotetrandrineCAS# 477-57-6 |
- Tetrandrine
Catalog No.:BCN5955
CAS No.:518-34-3
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 477-57-6 | SDF | Download SDF |
| PubChem ID | 457825 | Appearance | Powder |
| Formula | C38H42N2O6 | M.Wt | 622.8 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | (R,S)-Tetrandrine;Isosinomenine A;O,O'-Dimethylstepholine | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC | ||
| Standard InChIKey | WVTKBKWTSCPRNU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. 2. Isotetrandrine dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process. |
| Targets | IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK |
Isotetrandrine Dilution Calculator
Isotetrandrine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6057 mL | 8.0283 mL | 16.0565 mL | 32.113 mL | 40.1413 mL |
| 5 mM | 0.3211 mL | 1.6057 mL | 3.2113 mL | 6.4226 mL | 8.0283 mL |
| 10 mM | 0.1606 mL | 0.8028 mL | 1.6057 mL | 3.2113 mL | 4.0141 mL |
| 50 mM | 0.0321 mL | 0.1606 mL | 0.3211 mL | 0.6423 mL | 0.8028 mL |
| 100 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.3211 mL | 0.4014 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B.[Pubmed:24331940]
J Surg Res. 2014 Apr;187(2):596-604.
BACKGROUND: Mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappaB) signaling pathways are pleiotropic regulator of many genes involved in lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to reveal the protective effect of Isotetrandrine (ITD), a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. METHODS: In vitro, RAW 264.7 cells were pretreated with different dose of ITD 1 h before treatment with 1 mg/L of LPS. In vivo, to induce ALI, male BALB/c mice were injected intranasally with LPS and treated with ITD (20 and 40 mg/kg) 1 h before LPS. RESULTS: In vitro, the cytokine levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in supernatant were reduced by ITD. Meanwhile, in vivo, pulmonary inflammatory cell infiltration, myeloperoxidase activity, total cells, neutrophils, macrophages, along with the levels of tumor necrosis factor-alpha, IL-1beta, and IL-6 in bronchoalveolar lavage fluid were dose-dependently attenuated by ITD. Furthermore, our data showed that ITD significantly inhibited the activation of MAPK and NF-kappaB, which are induced by LPS in ALI model. CONCLUSIONS: These results suggested that ITD dose-dependently suppressed the severity of LPS-induced ALI by inactivation of MAPK and NF-kappaB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
