LycorenineCAS# 477-19-0 |
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| Cas No. | 477-19-0 | SDF | Download SDF |
| PubChem ID | 160472 | Appearance | Cryst. |
| Formula | C18H23NO4 | M.Wt | 317.38 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (5aR,7S,11bS,11cS)-9,10-dimethoxy-1-methyl-3,5,5a,7,11b,11c-hexahydro-2H-isochromeno[3,4-g]indol-7-ol | ||
| SMILES | CN1CCC2=CCC3C(C21)C4=CC(=C(C=C4C(O3)O)OC)OC | ||
| Standard InChIKey | VHYYSQODIQWPDO-PILAGYSTSA-N | ||
| Standard InChI | InChI=1S/C18H23NO4/c1-19-7-6-10-4-5-13-16(17(10)19)11-8-14(21-2)15(22-3)9-12(11)18(20)23-13/h4,8-9,13,16-18,20H,5-7H2,1-3H3/t13-,16-,17-,18+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. The development of tachyphylaxis to the vasodepressor action of lycorenine is ascribed to maintenance of its alpha-adrenergic blocking action. 2. Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. |
| Targets | Antifection |
Lycorenine Dilution Calculator
Lycorenine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1508 mL | 15.754 mL | 31.508 mL | 63.0159 mL | 78.7699 mL |
| 5 mM | 0.6302 mL | 3.1508 mL | 6.3016 mL | 12.6032 mL | 15.754 mL |
| 10 mM | 0.3151 mL | 1.5754 mL | 3.1508 mL | 6.3016 mL | 7.877 mL |
| 50 mM | 0.063 mL | 0.3151 mL | 0.6302 mL | 1.2603 mL | 1.5754 mL |
| 100 mM | 0.0315 mL | 0.1575 mL | 0.3151 mL | 0.6302 mL | 0.7877 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: II. Effects of blood pressure in rats and dogs and the mechanism of tachyphylaxis to the vasodepressor action of lycorenine in rats.[Pubmed:6110797]
Jpn J Pharmacol. 1980 Oct;30(5):655-64.
Blood pressure responses to Lycorenine were investigated in rats and dogs. Lycorenine (10--40 mg/kg p.o.) produced a decrease in blood pressure in conscious rats which was greater in hypertensive rats than in normotensive rats. In conscious dogs, Lycorenine (5 or 10 mg/kg i.v.) produced rises in blood pressure and heart rate except for a few instances, while it produced a decrease in blood pressure in pentobarbital anesthetized dogs. Thus, there are species differences in cardiovascular effects of Lycorenine between conscious rats and dogs. The development of tachyphylaxis to the vasodepressor actions of Lycorenine and its related compounds was related to their alpha-adrenergic blocking activities at the time of the second injection in anesthetized rats. Desipramine which abolished or diminished the development of tachyphylaxis to the vasodepressor action of Lycorenine (5 or 7.5 mg/kg i.v.), shortened the duration of its vasodepressor action and reduced its alpha-adrenergic blocking action. These results indicate that the development of tachyphylaxis to the vasodepressor action of Lycorenine is ascribed to maintenance of its alpha-adrenergic blocking action.
Preparation and antimalarial activity of semisynthetic lycorenine derivatives.[Pubmed:23567962]
Eur J Med Chem. 2013 May;63:722-30.
A set of twenty one Lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.
Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: Vasodepressor mechanism in rats.[Pubmed:537276]
Jpn J Pharmacol. 1979 Aug;29(4):605-22.
Vasodepressor mechanism of Lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1--10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarters, Lycorenine (62.5--500 micrograms i.a.) produced dose-related decreases both in mean blood pressure and in perfusion pressure, and the Lycorenine-induced decrease in perfusion pressure was abolished by phenoxybenzamine or hexamethonium. Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. Lycorenine (7.5 or 15 mg/kg i.v.) reduced the spontaneous splanchnic nerve activity. Lycorenine when given intracerebroventricularly produced decreases in blood pressure and heart rate only in large doses (over 500 micrograms). The maximal bradycardia induced by Lycorenine was abolished by bilateral vagotomy. It is suggested that Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity.
Total synthesis of the lycorenine-type amaryllidaceae alkaloid (+/-)-clivonine via a biomimetic ring-switch from a lycorine-type progenitor.[Pubmed:20235577]
J Am Chem Soc. 2010 Apr 14;132(14):5176-8.
A fully diastereoselective total synthesis of the Lycorenine-type Amaryllidaceae alkaloid (+/-)-clivonine (19) is reported via a route that employs for the first time a biomimetic ring-switch from a lycorine-type progenitor, thereby corroborating experimentally the biogenetic hypothesis first expounded for these compounds by Barton in 1960.
