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Isochondodendrine

CAS# 477-62-3

Isochondodendrine

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Quality Control of Isochondodendrine

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Chemical structure

Isochondodendrine

3D structure

Chemical Properties of Isochondodendrine

Cas No. 477-62-3 SDF Download SDF
PubChem ID 197726 Appearance Powder
Formula C36H38N2O6 M.Wt 594.7
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC=C(O3)C=C7)N(CCC6=CC(=C5O)OC)C)O)OC
Standard InChIKey XIOGHHPVBVXQIV-VSGBNLITSA-N
Standard InChI InChI=1S/C36H38N2O6/c1-37-15-13-23-19-29(41-3)33(39)35-31(23)27(37)17-21-5-9-26(10-6-21)44-36-32-24(20-30(42-4)34(36)40)14-16-38(2)28(32)18-22-7-11-25(43-35)12-8-22/h5-12,19-20,27-28,39-40H,13-18H2,1-4H3/t27-,28-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Isochondodendrine Dilution Calculator

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Isochondodendrine Molarity Calculator

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Preparing Stock Solutions of Isochondodendrine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6815 mL 8.4076 mL 16.8152 mL 33.6304 mL 42.038 mL
5 mM 0.3363 mL 1.6815 mL 3.363 mL 6.7261 mL 8.4076 mL
10 mM 0.1682 mL 0.8408 mL 1.6815 mL 3.363 mL 4.2038 mL
50 mM 0.0336 mL 0.1682 mL 0.3363 mL 0.6726 mL 0.8408 mL
100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3363 mL 0.4204 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isochondodendrine

Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum.[Pubmed:15996841]

J Ethnopharmacol. 2005 Oct 31;102(1):89-94.

Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, Isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 microg/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0.10 microg/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 microg/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50=1.83 microg/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms.

Description

Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum.

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