Demethyl tetrandrineCAS# 33889-68-8 |
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| Cas No. | 33889-68-8 | SDF | Download SDF |
| PubChem ID | 321937 | Appearance | Cryst. |
| Formula | C37H40N2O6 | M.Wt | 608.72 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC | ||
| Standard InChIKey | IIQSJHUEZBTSAT-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Stephania tetrandra S.Moore
| Description | Demethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively. |
| Targets | DNA/RNA Synthesis |
| In vitro | INHIBITION OF TETRANDRINE AND DEMETHYL TETRANDRINE ON DNA, RNA AND PROTEIN SYNTHESES OF LEUKEMIA 7712 AND SARCOMA 180 CELLS[Reference: WebLink]《Chinese Pharmacological Bulletin》 1990-01
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Demethyl tetrandrine Dilution Calculator
Demethyl tetrandrine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6428 mL | 8.214 mL | 16.4279 mL | 32.8558 mL | 41.0698 mL |
| 5 mM | 0.3286 mL | 1.6428 mL | 3.2856 mL | 6.5712 mL | 8.214 mL |
| 10 mM | 0.1643 mL | 0.8214 mL | 1.6428 mL | 3.2856 mL | 4.107 mL |
| 50 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.6571 mL | 0.8214 mL |
| 100 mM | 0.0164 mL | 0.0821 mL | 0.1643 mL | 0.3286 mL | 0.4107 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.
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