Eupaglehnin CCAS# 476630-49-6 |
Quality Control & MSDS
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| Cas No. | 476630-49-6 | SDF | Download SDF |
| PubChem ID | 131854185 | Appearance | Oil |
| Formula | C20H26O5 | M.Wt | 346.42 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(3aR,4R,6Z,10E,11aR)-6,10-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (Z)-2-(hydroxymethyl)but-2-enoate | ||
| SMILES | CC=C(CO)C(=O)OC1CC(=CCCC(=CC2C1C(=C)C(=O)O2)C)C | ||
| Standard InChIKey | LQAWDKQOLJURMN-VJQSGOAOSA-N | ||
| Standard InChI | InChI=1S/C20H26O5/c1-5-15(11-21)20(23)25-17-10-13(3)8-6-7-12(2)9-16-18(17)14(4)19(22)24-16/h5,8-9,16-18,21H,4,6-7,10-11H2,1-3H3/b12-9+,13-8-,15-5-/t16-,17-,18+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Eupatorium glehni.
| Description | 1. Eupaglehnin C shows cytotoxic (2.19 mg/ml) against HeLa-S3. |
Eupaglehnin C Dilution Calculator
Eupaglehnin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8867 mL | 14.4333 mL | 28.8667 mL | 57.7334 mL | 72.1667 mL |
| 5 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL | 11.5467 mL | 14.4333 mL |
| 10 mM | 0.2887 mL | 1.4433 mL | 2.8867 mL | 5.7733 mL | 7.2167 mL |
| 50 mM | 0.0577 mL | 0.2887 mL | 0.5773 mL | 1.1547 mL | 1.4433 mL |
| 100 mM | 0.0289 mL | 0.1443 mL | 0.2887 mL | 0.5773 mL | 0.7217 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni.
Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4.
We have been interested in biologically active terpenoids from Compositae9—14) and collected E. glehni6—8) in Tokushima and Hokkaido, Japan. From the ethyl acetate-soluble fraction of the methanol extract, we have found four new germacranolides with unsaturated esters at the 8-position, eupaglehnin A, eupaglehnin B, Eupaglehnin C, and eupaglehnin D, and two new chlorine atom-containing germacranolides, eupaglehnin E (5) and eupaglehnin F (6),13) as well as 2a-acetoxyepitulipinolide (7) for the first time from natural sources. In our attempt to find cytotoxic compounds, eupatoriopicrin (8) 24—29) was the most effective (1.40 mg/ml), followed by Eupaglehnin C (3) (2.19 mg/ml) against HeLa-S3. However, eupaglehnin E (5) and eupaglehnin F (6) did not show cytotoxic activity, which is understandable because they had no exomethylene group. In preliminary experiments, eupatoriopicrin (8) 24—26) also showed apoptotic activity against Ha-60 cell lines, the details of which will be published in due course.
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