PodophyllotoxinoneCAS# 477-49-6 |
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| Cas No. | 477-49-6 | SDF | Download SDF |
| PubChem ID | 443014 | Appearance | Powder |
| Formula | C22H20O8 | M.Wt | 412.39 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (5aR,8aR,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-[2]benzofuro[5,6-f][1,3]benzodioxole-5,8-dione | ||
| SMILES | COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(=O)C4=CC5=C(C=C24)OCO5 | ||
| Standard InChIKey | ISCQYPPCSYRZOT-BKTGTZMESA-N | ||
| Standard InChI | InChI=1S/C22H20O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-19H,8-9H2,1-3H3/t13-,18+,19-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Dysosma versipellis
| Description | 1. Podophyllotoxinone shows inhibitory activity against L1210 leukemia and KB cells in vitro. |
Podophyllotoxinone Dilution Calculator
Podophyllotoxinone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4249 mL | 12.1244 mL | 24.2489 mL | 48.4978 mL | 60.6222 mL |
| 5 mM | 0.485 mL | 2.4249 mL | 4.8498 mL | 9.6996 mL | 12.1244 mL |
| 10 mM | 0.2425 mL | 1.2124 mL | 2.4249 mL | 4.8498 mL | 6.0622 mL |
| 50 mM | 0.0485 mL | 0.2425 mL | 0.485 mL | 0.97 mL | 1.2124 mL |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2425 mL | 0.485 mL | 0.6062 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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SYNTHESIS AND ANTITUMOR ACTIVITY OF PODOPHYLLOTOXINONE AND ITS HYDROXYIMINO ANALOGUES
Chinese Journal of Pharmaceuticals, 1993.
Podophyllotoxinone and its hydroxyimino analogues have been synthesized by oxidation and oximation. The results of their inhibitory activities against L1210 leukemia and KB cells in vitro indicated that they were generally weaker than that of etoposide.
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