Calcium Channel - Membrane Transporter/Ion Channel

Cat.No. Product Name Information

BCC5690 Camstatin

BCC5239 Lercanidipine Lercanidipine is a calcium channel blocker of the dihydropyridine class.

BCC7971 Gadolinium chloride

BCC4403 Lacidipine Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.

BCC5700 ω-Conotoxin GVIA

BCC7303 CGS 9343B Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR. CGS 9343B

BCC7767 Efonidipine hydrochloride monoethanolate Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).

BCC7067 Ruthenium Red

BCC4397 Amlodipine Besylate Amlodipine besylate is a long-acting calcium channel blocker.

BCC6089 cis-Ned 19

BCC1748 Mibefradil Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.

BCC1749 Mibefradil dihydrochloride Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.

BCC7112 STO-609 acetate

BCC7050 FPL 64176

BCC7181 SR 33805 oxalate

BCC4400 Azelnidipine Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.

BCC1083 Cilnidipine Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

BCC5238 Lercanidipine hydrochloride Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.

BCC1915 Safinamide Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.

BCC6207 ML 218 hydrochloride ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier. ML 218 hydrochloride

BCC7825 trans-Ned 19 trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations.

BCC3858 Strontium Ranelate Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate also can activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling.

BCC4399 Tetracaine HCl Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

BCC7488 ω-Agatoxin IVA

BCC5873 CALP1 CALP1

BCC6673 Dantrolene, sodium salt

BCC5699 ω-Conotoxin MVIIC

BCN2175 Pregabalin

BCC4747 Verapamil HCl Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel antagonist.

BCC5742 Ryanodine Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

BCC7489 ω-Agatoxin TK

BCC8041 Huwentoxin XVI Potent and reversible N-type Ca<sup>2+</sup> channel blocker

BCC7153 Autocamtide-2-related inhibitory peptide Selective CaM kinase II inhibitor

BCC4401 Clevidipine Butyrate Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.

BCC8038 TRAM 39 Potent K<sub>Ca</sub>3.1 blocker TRAM 39

BCC5952 SNX 482 SNX 482

BCC7706 PD 173212 PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

BCC7817 YM 58483 YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals.

BCC5898 CALP2 CALP2

BCC5900 CALP3 CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia. CALP3

BCC4398 Flunarizine 2HCl Flunarizine is a selective calcium entry blocker.

BCC1803 NNC 55-0396 NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

BCC4381 Nitrendipine Nitrendipine is a calcium channel blocker with marked vasodilator action.

BCC1807 NP118809 NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.

BCC4239 Gabapentin enacarbil Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin.

BCC6255 ProTx I ProTx I

BCC6978 2-APB 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). 2-APB

BCC6980 A23187, free acid Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. Calcimycin induces apoptosis. A23187, free acid

BCN2202 Dehydroepiandrosterone DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors. Dehydroepiandrosterone

BCC7198 MRS 1845 MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM. MRS1845 is an ORAI1 inhibitor.

BCC7808 NAADP tetrasodium salt

BCC7261 Ionomycin free acid Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC). Ionomycin free acid

BCC5805 Ionomycin calcium salt Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC). Ionomycin calcium salt

BCC7410 Calmidazolium chloride Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to CaMK with a Kd of 3 nM. Calmidazolium chloride

BCC4502 Gabapentin HCl Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog.

BCC6811 DHBP dibromide DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

BCC6621 W-5 hydrochloride

BCC6622 W-7 hydrochloride

BCC4809 Nisoldipine Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

BCC7864 Bepridil hydrochloride Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.

BCC2512 Zonisamide Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.

BCC4240 Zonisamide sodium Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.

BCC6623 W-9 hydrochloride

BCC4402 Felodipine Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker.

BCC3799 Nilvadipine Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.

BCC3797 Isradipine (Dynacirc) Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.

BCC6625 A-7 hydrochloride

BCC4396 Amlodipine Amlodipine is a long-acting calcium channel blocker.

BCC6620 W-13 hydrochloride

BCC7002 (-)-Xestospongin C

BCC4404 Manidipine Manidipine is a calcium channel blocker that is used clinically as an antihypertensive.

BCC4405 Manidipine 2HCl Manidipine dihydrochloride (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

BCC4395 Benidipine HCl Benidipine hydrochloride is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension).

BCC2503 Ranolazine 2HCl Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor. Ranolazine 2HCl

BCC7108 (S)-(-)-Bay K 8644 (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

BCC7107 (R)-(+)-Bay K 8644 (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

BCC7561 L-651,582 Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.

Products for Calcium Channel