ML 218 hydrochloride

CAS# 1346233-68-8

ML 218 hydrochloride

Catalog No. BCC6207----Order now to get a substantial discount!

Product Name & Size Price Stock
ML 218 hydrochloride: 5mg $115 In Stock
ML 218 hydrochloride: 10mg Please Inquire In Stock
ML 218 hydrochloride: 20mg Please Inquire Please Inquire
ML 218 hydrochloride: 50mg Please Inquire Please Inquire
ML 218 hydrochloride: 100mg Please Inquire Please Inquire
ML 218 hydrochloride: 200mg Please Inquire Please Inquire
ML 218 hydrochloride: 500mg Please Inquire Please Inquire
ML 218 hydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of ML 218 hydrochloride

Number of papers citing our products

Chemical structure

ML 218 hydrochloride

3D structure

Chemical Properties of ML 218 hydrochloride

Cas No. 1346233-68-8 SDF Download SDF
PubChem ID 45115620 Appearance Powder
Formula C19H26Cl2N2O M.Wt 369.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name 3,5-dichloro-N-[[(1R,5S)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]benzamide
SMILES CC(C)(C)CCN1CC2C(C1)C2CNC(=O)C3=CC(=CC(=C3)Cl)Cl
Standard InChIKey GSJIGYLGKSBYBC-ALOPSCKCSA-N
Standard InChI InChI=1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15?,16-,17+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of ML 218 hydrochloride

DescriptionSelective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. Orally active.

ML 218 hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

ML 218 hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of ML 218 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7078 mL 13.5391 mL 27.0783 mL 54.1565 mL 67.6956 mL
5 mM 0.5416 mL 2.7078 mL 5.4157 mL 10.8313 mL 13.5391 mL
10 mM 0.2708 mL 1.3539 mL 2.7078 mL 5.4157 mL 6.7696 mL
50 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.0831 mL 1.3539 mL
100 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.5416 mL 0.677 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

Description

ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

Keywords:

ML 218 hydrochloride,1346233-68-8,Natural Products,Calcium Channel, buy ML 218 hydrochloride , ML 218 hydrochloride supplier , purchase ML 218 hydrochloride , ML 218 hydrochloride cost , ML 218 hydrochloride manufacturer , order ML 218 hydrochloride , high purity ML 218 hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: