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5,7-Di-O-methylquercetin

CAS# 13459-07-9

5,7-Di-O-methylquercetin

2D Structure

Catalog No. BCN3386----Order now to get a substantial discount!

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Quality Control of 5,7-Di-O-methylquercetin

3D structure

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5,7-Di-O-methylquercetin

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Chemical Properties of 5,7-Di-O-methylquercetin

Cas No. 13459-07-9 SDF Download SDF
PubChem ID 26034 Appearance Yellow cryst.
Formula C17H14O7 M.Wt 330.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-3-hydroxy-5,7-dimethoxychromen-4-one
SMILES COC1=CC(=C2C(=C1)OC(=C(C2=O)O)C3=CC(=C(C=C3)O)O)OC
Standard InChIKey FXGCMNIMMTVBFZ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,7-Di-O-methylquercetin

The branch of Rhamnus cathartica

Biological Activity of 5,7-Di-O-methylquercetin

Description1. 5,7-Di-O-methylquercetin is a genotoxic compound from S. skinneri.

5,7-Di-O-methylquercetin Dilution Calculator

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5,7-Di-O-methylquercetin Molarity Calculator

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Preparing Stock Solutions of 5,7-Di-O-methylquercetin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,7-Di-O-methylquercetin

Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium.[Pubmed:368618]

Mutat Res. 1978 Dec;54(3):297-309.

40 compounds structurally related to the plant flavonol quercetin were tested for mutagenic activity in Salmonella typhimurium strain TA98. 10 flavonols, quercetin, myricetin, rhamnetin, galangin, kaempferol, tamarixetin, morin, 3'-O-methylquercetin, 7,4'-di-O-methylquercetin and 5,7-di-O-methyl-quercetin, exhibited unequivocal mutagenic activity. 4 compounds, quercetin, myricetin, rhamnetin and 5,7-Di-O-methylquercetin, were active without metabolic activation, although metabolic activation markedly enhanced their activity. All 4 have free hydroxyl groups at the 3' and 4' positions of the B ring. The other active compounds required an in vitro rat-liver metabolizing system for significant activity. Structural features which appear essential for mutagenic activity in this strain are a basic flavanoid ring structure with (1) a free hydroxyl group at the 3 position, (2) a double bond at the 2, 3 position, (3) a keto group at the 4 position, and (4) a structure which permits the proton of the 3-hydroxyl group to tautomerise to a 3-keto compound. The data are consistent with the requirement for a B ring structure that permits oxidation to quininoid intermediates. Free hydroxyl groups in the B ring are not essential for activity if a rat-liver metabolic activating system is employed. Data from 12 compounds which differ only at the essential sites described above indicate that the structural requirements for mutagenicity in strain TA100 are the same as those for activity in strain TA98. Based on the above structural requirements, a metabolic pathway for flavonol activation to DNA-reactive species is proposed.

Use of the SOS-chromotest spot assay as a screening system for detecting genotoxic compounds in crude plant extracts.[Pubmed:11827573]

Altern Lab Anim. 2002 Jan-Feb;30(1):87-92.

An SOS-chromotest spot assay was used to detect genotoxic compounds in crude plant extracts. The method allows simultaneous testing of extracts from different species in either a liquid or a solid crystalline form. Extracts from two species of the genus Senna, native to the state of Morelos, Mexico, were assayed. Four genotoxic compounds were isolated, and were identified as quercetin and rutin from S. wislizeni, and 5,7-di- O-methylrutin and 5,7-Di-O-methylquercetin from S. skinneri. The SOS-chromotest spot assay proved to be useful for activity- guided fractionation at the beginning of screening for genotoxic compounds in crude plant extracts.

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