Tetracaine HClAnaesthetic and allosteric inhibitor CAS# 136-47-0 |
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| Cas No. | 136-47-0 | SDF | Download SDF |
| PubChem ID | 8695 | Appearance | Powder |
| Formula | C15H25ClN2O2 | M.Wt | 300.82 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride | ||
| SMILES | [H+].[Cl-].CCCCNc1ccc(cc1)C(=O)OCCN(C)C | ||
| Standard InChIKey | PPWHTZKZQNXVAE-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Tetracaine HCl Dilution Calculator
Tetracaine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3242 mL | 16.6212 mL | 33.2425 mL | 66.4849 mL | 83.1062 mL |
| 5 mM | 0.6648 mL | 3.3242 mL | 6.6485 mL | 13.297 mL | 16.6212 mL |
| 10 mM | 0.3324 mL | 1.6621 mL | 3.3242 mL | 6.6485 mL | 8.3106 mL |
| 50 mM | 0.0665 mL | 0.3324 mL | 0.6648 mL | 1.3297 mL | 1.6621 mL |
| 100 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.6648 mL | 0.8311 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local
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Apparent respiration rate of the human corneal epithelium with tetracaine HCl and benoxinate HCl.[Pubmed:6660279]
Am J Optom Physiol Opt. 1983 Dec;60(12):960-3.
Local anesthetics may have a cytotoxic effect which causes a depression in the apparent epithelial oxygen uptake rate (AEOR) of the cornea. We measured the AEOR of human corneas in vivo before and after applying 1% tetracaine (amethocaine) HCl and 0.4% benoxinate HCl. These drugs had no effect on AEOR. In human corneas that had been subjected to a period of hypoxia, AEOR was slightly higher after administration of benoxinate, a result in the opposite direction to that expected on the grounds of toxicity. The increase was not statistically significant. We conclude that clinical doses of Tetracaine HCl and benoxinate HCl normally have a minimal cytotoxic effect, and that this is similarly true when benoxinate is applied to the cornea after contact lens wear.
Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
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