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2-Amino-3-Formylchromone

CAS# 61424-76-8

2-Amino-3-Formylchromone

Catalog No. BCC8526----Order now to get a substantial discount!

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2-Amino-3-Formylchromone: 5mg $17 In Stock
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Chemical structure

2-Amino-3-Formylchromone

3D structure

Chemical Properties of 2-Amino-3-Formylchromone

Cas No. 61424-76-8 SDF Download SDF
PubChem ID 735928 Appearance Powder
Formula C10H7NO3 M.Wt 189
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-amino-4-oxochromene-3-carbaldehyde
SMILES C1=CC=C2C(=C1)C(=O)C(=C(O2)N)C=O
Standard InChIKey TVGIYZVZBKAJRR-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H7NO3/c11-10-7(5-12)9(13)6-3-1-2-4-8(6)14-10/h1-5H,11H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

2-Amino-3-Formylchromone Dilution Calculator

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2-Amino-3-Formylchromone Molarity Calculator

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Preparing Stock Solutions of 2-Amino-3-Formylchromone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.291 mL 26.455 mL 52.9101 mL 105.8201 mL 132.2751 mL
5 mM 1.0582 mL 5.291 mL 10.582 mL 21.164 mL 26.455 mL
10 mM 0.5291 mL 2.6455 mL 5.291 mL 10.582 mL 13.2275 mL
50 mM 0.1058 mL 0.5291 mL 1.0582 mL 2.1164 mL 2.6455 mL
100 mM 0.0529 mL 0.2646 mL 0.5291 mL 1.0582 mL 1.3228 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Amino-3-Formylchromone

Enantiomeric specificity of biologically significant Cu(II) and Zn(II) chromone complexes towards DNA.[Pubmed:23001645]

Chirality. 2012 Dec;24(12):977-86.

Novel chiral Schiff base ligands (R)/(S)-2-amino-3-(((1-hydroxypropan-2-yl)imino)methyl)-4H-chromen-4-one (L(1) and L(2)) derived from 2-Amino-3-Formylchromone and (R/S)-2-amino-1-propanol and their Cu(II)/Zn(II) complexes (R1, S1, R2, and S2) were synthesized. The complexes were characterized by elemental analysis, infrared (IR), hydrogen ((1) H) and carbon ((13)C) nuclear magnetic resonance (NMR), electrospray ionization-mass spectra (ESI-MS), and molar conductance measurements. The DNA binding studies of the complexes with calf thymus were carried out by employing different biophysical methods and molecular docking studies that revealed that complexes R1 and S1 prefers the guanine-cytosine-rich region, whereas R2 and prefers the adenine-thymine residues in the major groove of DNA. The relative trend in K(b) values followed the order R1>S1>R2>S2. This observation together with the findings of circular dichroic and fluorescence studies revealed maximal potential of (R)-enantiomeric form of complexes to bind DNA. Furthermore, the absorption studies with mononucleotides were also monitored to examine the base-specific interactions of the complexes that revealed a higher propensity of Cu(II) complexes for guanosine-5'-monophosphate disodium salt, whereas Zn(II) complexes preferentially bind to thymidine-5'-monophosphate disodium salt. The cleavage activity of R1 and R2 with pBR322 plasmid DNA was examined by gel electrophoresis that revealed that they are good DNA cleavage agents; nevertheless, R1 proved to show better DNA cleavage ability. Topoisomerase II inhibitory activity of complex R1 revealed that the complex inhibits topoisomerase II catalytic activity at a very low concentration (25 muM). Furthermore, in vitro antitumor activity of complexes R1 and S1 were screened against human carcinoma cell lines of different histological origin.

Synthesis of new chiral heterocyclic Schiff base modulated Cu(II)/Zn(II) complexes: their comparative binding studies with CT-DNA, mononucleotides and cleavage activity.[Pubmed:21459607]

J Photochem Photobiol B. 2011 May 3;103(2):166-79.

New Schiff base ligand L derived from the condensation reaction of 2-Amino-3-Formylchromone with (R)-2-amino-2-phenylethanol was synthesized and characterized which involves combination element of ammine functionality and naturally occurring heterocyclic chromone, 4H-benzopyran-4-one. Subsequently, their complexes 1 and 2 with Cu(NO(3))(2) and Zn(NO(3))(2), respectively were prepared. The DNA binding studies of the ligand L and complexes 1 and 2 with CT-DNA as compared to classical anticancer drug cisplatin were carried out by employing different optical methods viz, UV-vis, fluorescence, circular dichroism and viscosity measurements. Furthermore, the absorption studies, (1)H and (3)(1)P with mononucleotides were also monitored to examine the base specific interactions of the transition metal complexes which revealed a higher propensity of copper(II) complex 1 for 5'-GMP while for zinc(II) complex 2 towards 5'-TMP involving groove binding mechanism of the complexes towards DNA. The complex 1 exhibits a remarkable DNA cleavage activity with pBR322 DNA in presence of different activators and cleavage reaction involves various oxygen species suggesting the involvement of active oxygen species for the DNA scission.

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