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Acetylatractylodinol

CAS# 61582-39-6

Acetylatractylodinol

Catalog No. BCN8111----Order now to get a substantial discount!

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Quality Control of Acetylatractylodinol

Number of papers citing our products

Chemical structure

Acetylatractylodinol

3D structure

Chemical Properties of Acetylatractylodinol

Cas No. 61582-39-6 SDF Download SDF
PubChem ID 5315531 Appearance Powder
Formula C15H12O3 M.Wt 240.25
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2E,8E)-9-(furan-2-yl)nona-2,8-dien-4,6-diynyl] acetate
SMILES CC(=O)OCC=CC#CC#CC=CC1=CC=CO1
Standard InChIKey KQELYEKOTPXIHM-NBANWCDVSA-N
Standard InChI InChI=1S/C15H12O3/c1-14(16)17-12-8-6-4-2-3-5-7-10-15-11-9-13-18-15/h6-11,13H,12H2,1H3/b8-6+,10-7+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Acetylatractylodinol

The root of Atractylodes chinensis

Biological Activity of Acetylatractylodinol

In vitro

Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity.[Pubmed: 11488458 ]

Planta Med. 2001 Jul;67(5):437-42.


METHODS AND RESULTS:
From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (1) was isolated as a new natural product. The compound showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 microM (5-LOX), 2 microM (COX-1), 9 microM (PMN/FMLP), 28 microM (PMNIOZ)]. Moreover, five new acetylenes were isolated and elucidated as (3Z,5E,11E)-tridecatriene-7,9-diynyl-1-O-(E)-ferulate (2), erythro-(1,3Z,11E)-tridecatriene-7,9-diyne-5,6-diyl diacetate (3), (1Z)-atractylodin (4), (1Z)-atractylodinol (5), (1Z)-Acetylatractylodinol (6) plus the known (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate (7).
CONCLUSIONS:
Among the acetylenes, only 2 showed strong inhibition of 5-LOX and COX-1 activity (IC50 (5-LOX) = 3 microM, IC50 (COX-1) = 1 microM). In addition, the fatty acids linoleic acid, oleic acid and palmitic acid with previously established 5-LOX-/COX-1 inhibitory actions were identified as major constituents of the n-hexane extract and thus seem to contribute to the plant's in vitro activity.

Antioxidant activity of constituents from Atractylodes lancea.[Reference: WebLink]

Pharmaceutical and pharmacological letters,1998,8(2):69-71.

Four polyacetylenes atractylodin, Acetylatractylodinol, 1-(2-furyl)-(7E)-nonene-3,5-diyne-1,2-diacetate, erythro-(1,5E, 11E)-tridecatriene-7,9-diyne-3,4-diacetate,as well as atractylochromene (I) and 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2,5-cyclohexadiene-1,4-dione (II) isolated from the rhizomes of Atractylodes lancea were evaluated for their antioxidant activity ex vivo.
METHODS AND RESULTS:
When measuring the inhibition of luminal enhanced chemiluminescence in stimulated human neutrophils, only the chromene I and the quinone II showed strong antioxidant activity. After stimulation with FMLP or opsonized zymosan (OZ) both compds. exhibited comparable inhibitory effects (IC50 I = 1.3 micro M (FMLP), 5.6 micro M (OZ); IC50 II = 1.1 micro M (FMLP), 5.4 micro M (OZ)). In contrast, I was considerably more active in a cell free in vitro assay with H2O2 and horseradish peroxidase (IC50 = 4.9 micro M I, 11 micro M II).

Acetylatractylodinol Dilution Calculator

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Preparing Stock Solutions of Acetylatractylodinol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1623 mL 20.8117 mL 41.6233 mL 83.2466 mL 104.0583 mL
5 mM 0.8325 mL 4.1623 mL 8.3247 mL 16.6493 mL 20.8117 mL
10 mM 0.4162 mL 2.0812 mL 4.1623 mL 8.3247 mL 10.4058 mL
50 mM 0.0832 mL 0.4162 mL 0.8325 mL 1.6649 mL 2.0812 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 0.8325 mL 1.0406 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Acetylatractylodinol

Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity.[Pubmed:11488458]

Planta Med. 2001 Jul;67(5):437-42.

From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (1) was isolated as a new natural product. The compound showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 microM (5-LOX), 2 microM (COX-1), 9 microM (PMN/FMLP), 28 microM (PMNIOZ)]. Moreover, five new acetylenes were isolated and elucidated as (3Z,5E,11E)-tridecatriene-7,9-diynyl-1-O-(E)-ferulate (2), erythro-(1,3Z,11E)-tridecatriene-7,9-diyne-5,6-diyl diacetate (3), (1Z)-atractylodin (4), (1Z)-atractylodinol (5), (1Z)-Acetylatractylodinol (6) plus the known (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate (7). Among the acetylenes, only 2 showed strong inhibition of 5-LOX and COX-1 activity (IC50 (5-LOX) = 3 microM, IC50 (COX-1) = 1 microM). In addition, the fatty acids linoleic acid, oleic acid and palmitic acid with previously established 5-LOX-/COX-1 inhibitory actions were identified as major constituents of the n-hexane extract and thus seem to contribute to the plant's in vitro activity.

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