BMS-983970CAS# 1584713-87-0 |
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Quality Control & MSDS
3D structure
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| Cas No. | 1584713-87-0 | SDF | Download SDF |
| PubChem ID | 122173020 | Appearance | Powder |
| Formula | C26H26F4N4O3 | M.Wt | 518.5 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 50 mg/mL (96.43 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (4S,5R)-4-(cyclopropylmethyl)-1-[(3R)-9-fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-5-(3,3,3-trifluoropropyl)diazinane-3,6-dione | ||
| SMILES | C1CC1CC2C(C(=O)N(NC2=O)C3C(=O)NC4=C(C=CC=C4F)C(=N3)C5=CC=CC=C5)CCC(F)(F)F | ||
| Standard InChIKey | RLQVHGIJVONFRM-TVTNDZMWSA-N | ||
| Standard InChI | InChI=1S/C26H24F4N4O3/c27-19-8-4-7-17-20(15-5-2-1-3-6-15)31-22(24(36)32-21(17)19)34-25(37)16(11-12-26(28,29)30)18(23(35)33-34)13-14-9-10-14/h1-8,14,16,18,22H,9-13H2,(H,32,36)(H,33,35)/t16-,18+,22-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
BMS-983970 Dilution Calculator
BMS-983970 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9286 mL | 9.6432 mL | 19.2864 mL | 38.5728 mL | 48.216 mL |
| 5 mM | 0.3857 mL | 1.9286 mL | 3.8573 mL | 7.7146 mL | 9.6432 mL |
| 10 mM | 0.1929 mL | 0.9643 mL | 1.9286 mL | 3.8573 mL | 4.8216 mL |
| 50 mM | 0.0386 mL | 0.1929 mL | 0.3857 mL | 0.7715 mL | 0.9643 mL |
| 100 mM | 0.0193 mL | 0.0964 mL | 0.1929 mL | 0.3857 mL | 0.4822 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.
References:
[1]. Ashvinikumar V. Gavai, et al. Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer
. Cancer Res October 1, 2014 74; 1643
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BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers.
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