Chitinase-IN-2CAS# 1579991-63-1 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1579991-63-1 | SDF | Download SDF |
| PubChem ID | 86223064 | Appearance | Powder |
| Formula | C20H21N5O2S | M.Wt | 395.48 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 53 mg/mL (134.01 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 6-(dimethylamino)-2-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)methylamino]ethyl]benzo[de]isoquinoline-1,3-dione | ||
| SMILES | CC1=NN=C(S1)CNCCN2C(=O)C3=C4C(=C(C=C3)N(C)C)C=CC=C4C2=O | ||
| Standard InChIKey | MZVBLDCRQKXSHR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H21N5O2S/c1-12-22-23-17(28-12)11-21-9-10-25-19(26)14-6-4-5-13-16(24(2)3)8-7-15(18(13)14)20(25)27/h4-8,21H,9-11H2,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Chitinase-IN-2 Dilution Calculator
Chitinase-IN-2 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5286 mL | 12.6429 mL | 25.2857 mL | 50.5715 mL | 63.2143 mL |
| 5 mM | 0.5057 mL | 2.5286 mL | 5.0571 mL | 10.1143 mL | 12.6429 mL |
| 10 mM | 0.2529 mL | 1.2643 mL | 2.5286 mL | 5.0571 mL | 6.3214 mL |
| 50 mM | 0.0506 mL | 0.2529 mL | 0.5057 mL | 1.0114 mL | 1.2643 mL |
| 100 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.5057 mL | 0.6321 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 μM/20 μM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively.
References:
[1]. thalimide derivative and application thereof as enzyme inhibitor and pesticide . Patent CN 103641825 A
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Chitinase1 contributed to a potential protection via microglia polarization and Abeta oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments.[Pubmed:28499970]
Neuroscience. 2017 Jul 4;355:61-70.
Chitinase activity is increased in Alzheimer's disease (AD). However, the role of chitinase1 in AD is unknown. We investigated the effects of chitinase1 on Alzheimer's pathology and microglia function. Artificial chitinase1 and chitinase inhibitor (Chitinase-IN-2) were used to determine the effects of chitinase1 on inflammatory factors and beta-amyloid (Abeta) oligomers deposition in D-galactose/AlCl3-induced rat model with cognitive impairments. Abeta-treated N9 microglia cells were analyzed to further verify whether the changes in inflammatory factors following chitinase1 treatment were associated with microglia alternative activation. Our data displayed that the activity of chitinase1 was both improved in D-galactose/AlCl3-injected rats and Abeta-pretreated microglia. Moreover, there was an improvement in cognitive function in chitinase1-treated AD rats. Furthermore, anti-inflammation factors (Arginase 1, Arg-1, mannose receptor type C 1, MRC1/CD206) were increased and pro-inflammation factors (tumor necrosis factor alpha, TNFalpha, interleukin 1 beta, IL-1beta) were decreased in D-galactose/AlCl3-induced AD rats with chitinase1 treatment. A higher level of M2 markers (Arg-1, MRC1/CD206) and a lower level of classic M1 markers (TNFa, IL-1beta) were obtained in Abeta-pretreated N9 cells with chitinase1, suggesting that chitinase1 polarized the microglia into an anti-AD M2 phenotype. We also detected that chitnase1 could weaken the deposition of Abeta oligomers in the brain of D-galactose/ AlCl3-induced AD rats. In conclusion, Chitinase1 might exert protective effects against AD by polarizing microglia to an M2 phenotype and resisting Abeta oligomer deposition.
