5-Benzimidazolecarboxylic acidCAS# 15788-16-6 |
Quality Control & MSDS
3D structure
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| Cas No. | 15788-16-6 | SDF | Download SDF |
| PubChem ID | 459456 | Appearance | Powder |
| Formula | C8H6N2O2 | M.Wt | 162 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3H-benzimidazole-5-carboxylic acid | ||
| SMILES | C1=CC2=C(C=C1C(=O)O)NC=N2 | ||
| Standard InChIKey | COYPLDIXZODDDL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H6N2O2/c11-8(12)5-1-2-6-7(3-5)10-4-9-6/h1-4H,(H,9,10)(H,11,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
5-Benzimidazolecarboxylic acid Dilution Calculator
5-Benzimidazolecarboxylic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.1728 mL | 30.8642 mL | 61.7284 mL | 123.4568 mL | 154.321 mL |
| 5 mM | 1.2346 mL | 6.1728 mL | 12.3457 mL | 24.6914 mL | 30.8642 mL |
| 10 mM | 0.6173 mL | 3.0864 mL | 6.1728 mL | 12.3457 mL | 15.4321 mL |
| 50 mM | 0.1235 mL | 0.6173 mL | 1.2346 mL | 2.4691 mL | 3.0864 mL |
| 100 mM | 0.0617 mL | 0.3086 mL | 0.6173 mL | 1.2346 mL | 1.5432 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Methods for generation of monoclonal antibodies to the very small drug hapten, 5-benzimidazolecarboxylic acid.[Pubmed:12445730]
J Immunol Methods. 2002 Dec 20;271(1-2):65-75.
Drug-specific monoclonal antibodies (MAbs) were produced against the very small drug hapten (162.15 Da), 5-Benzimidazolecarboxylic acid, an analogue of 2-(4-Thiazolyl)benzimidazole (TBZ) but lacking the thiol group. TBZ is widely used as a broad-spectrum anthelmintic in various animal species and humans and also as a food preservative and agricultural fungicide. The anti-5-Benzimidazolecarboxylic acid antibodies produced have potential use for extraction and/or detection of protein-bound residue forms of TBZ. Three in vivo immunisation regimes (with combinations of two related small drug haptens and two different adjuvants/carrier molecules) and an in vitro immunisation procedure using a combination of three related unconjugated small drug haptens were investigated. Specificity for the hapten immunogen/s was initially determined using two different ELISA procedures. BIACORE analysis, in conjunction with drug binding inhibition studies, was used to confirm the specificity of a small number of selected clones. In vivo immunisation with a drug molecule conjugated to a lipopeptide/T-cell epitope, which acts both as a carrier molecule and an adjuvant was the most useful of the methods tested for the production of specific MAbs to a typically very small hapten with low immunogenic properties.
