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7-Xylosyl-10-deacetylbaccatin III

CAS# 157664-03-4

7-Xylosyl-10-deacetylbaccatin III

Catalog No. BCN7668----Order now to get a substantial discount!

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7-Xylosyl-10-deacetylbaccatin III: 5mg Please Inquire In Stock
7-Xylosyl-10-deacetylbaccatin III: 10mg Please Inquire In Stock
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Quality Control of 7-Xylosyl-10-deacetylbaccatin III

Number of papers citing our products

Chemical structure

7-Xylosyl-10-deacetylbaccatin III

3D structure

Chemical Properties of 7-Xylosyl-10-deacetylbaccatin III

Cas No. 157664-03-4 SDF Download SDF
PubChem ID 5315356 Appearance Powder
Formula C34H44O14 M.Wt 676.70
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)OC6C(C(C(CO6)O)O)O)C)O
Standard InChIKey PAYIYFPUFSJTDA-HEJNHQNCSA-N
Standard InChI InChI=1S/C34H44O14/c1-15-18(36)12-34(43)28(47-29(42)17-9-7-6-8-10-17)26-32(5,27(41)24(39)22(15)31(34,3)4)20(11-21-33(26,14-45-21)48-16(2)35)46-30-25(40)23(38)19(37)13-44-30/h6-10,18-21,23-26,28,30,36-40,43H,11-14H2,1-5H3/t18-,19+,20-,21+,23-,24+,25+,26-,28-,30-,32+,33-,34+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-Xylosyl-10-deacetylbaccatin III

The barks of Taxus brevifolia.

Biological Activity of 7-Xylosyl-10-deacetylbaccatin III

Description7-Xylosyl-10-deacetylbaccatin III is a natural product from Taxus brevifolia.

Protocol of 7-Xylosyl-10-deacetylbaccatin III

Structure Identification
Biotechnology & Applied Biochemistry, 1997, 26(3):153-158.

Enzymic hydrolysis of 7-xylosyltaxanes by xylosidase from Moraxella sp.[Reference: WebLink]

The production of large quantities of paclitaxel for use as an anticancer treatment has been a difficult problem because of the low concentration of the compound in yew trees (Taxus sp.) and its occurrence as part of a mixture of other taxanes. 7-Xylosyltaxanes are major components of the mixture found in the bark of the Pacific yew (Taxus brevifolia).
METHODS AND RESULTS:
A bacterial strain isolated from soil and identified as a Moraxella sp. was able to remove the xylosyl group from 7-xylosylpaclitaxel 7-xylosyl-10-deacetylpaclitaxel, 7-xylosylbaccatin III and 7-Xylosyl-10-deacetylbaccatin III, thereby making the xylosyltaxanes available as sources of 10-deacetylbaccatin III for semisynthesis of paclitaxel.
CONCLUSIONS:
The activity was located in both the soluble and particulate fractions of the cell.

7-Xylosyl-10-deacetylbaccatin III Dilution Calculator

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7-Xylosyl-10-deacetylbaccatin III Molarity Calculator

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Preparing Stock Solutions of 7-Xylosyl-10-deacetylbaccatin III

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4778 mL 7.3888 mL 14.7776 mL 29.5552 mL 36.944 mL
5 mM 0.2956 mL 1.4778 mL 2.9555 mL 5.911 mL 7.3888 mL
10 mM 0.1478 mL 0.7389 mL 1.4778 mL 2.9555 mL 3.6944 mL
50 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.5911 mL 0.7389 mL
100 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.2956 mL 0.3694 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7-Xylosyl-10-deacetylbaccatin III

Bacterial diversity of Taxus rhizosphere: culture-independent and culture-dependent approaches.[Pubmed:18576948]

FEMS Microbiol Lett. 2008 Jul;284(2):204-12.

The regional variability of Taxus rhizosphere bacterial community composition and diversity was studied by comparative analysis of three large 16S rRNA gene clone libraries from the Taxus rhizosphere in different regions of China (subtropical and temperate regions). One hundred and forty-six clones were screened for three libraries. Phylogenetic analysis of 16S rRNA gene sequences demonstrated that the abundance of sequences affiliated with Gammaproteobacteria, Betaproteobacteria, and Actinobacteria was higher in the library from the T. xmedia rhizosphere of the temperate region compared with the subtropical Taxus mairei rhizosphere. On the other hand, Acidobacteria was more abundant in libraries from the subtropical Taxus mairei rhizosphere. Richness estimates and diversity indices of three libraries revealed major differences, indicating a higher richness in the Taxus rhizosphere bacterial communities of the subtropical region and considerable variability in the bacterial community composition within this region. By enrichment culture, a novel Actinobacteria strain DICP16 was isolated from the T. xmedia rhizosphere of the temperate region and was identified as Leifsonia shinshuensis sp. via 16S rRNA gene and gyrase B sequence analyses. DICP16 was able to remove the xylosyl group from 7-Xylosyl-10-deacetylbaccatin III and 7-xylosyl-10-deacetylpaclitaxel, thereby making the xylosyltaxanes available as sources of 10-deacetylbaccatin III and the anticancer drug paclitaxel. Taken together, the present studies provide, for the first time, the knowledge of the biodiversity of microorganisms populating Taxus rhizospheres.

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