Escin IIBCAS# 158800-83-0 |
- Aescin IIA
Catalog No.:BCN6551
CAS No.:158732-55-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 158800-83-0 | SDF | Download SDF |
| PubChem ID | 10260627 | Appearance | Powder |
| Formula | C54H84O23 | M.Wt | 1101.24 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid | ||
| SMILES | CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(CO8)O)O)O)C)CO)OC(=O)C | ||
| Standard InChIKey | MLLNRQWNTKNRGQ-GJSMMZDWSA-N | ||
| Standard InChI | InChI=1S/C54H84O23/c1-10-23(2)45(69)77-42-43(71-24(3)58)54(22-57)26(17-49(42,4)5)25-11-12-30-50(6)15-14-32(51(7,21-56)29(50)13-16-52(30,8)53(25,9)18-31(54)60)73-48-40(75-46-36(64)33(61)27(59)20-70-46)38(66)39(41(76-48)44(67)68)74-47-37(65)35(63)34(62)28(19-55)72-47/h10-11,26-43,46-48,55-57,59-66H,12-22H2,1-9H3,(H,67,68)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33-,34+,35-,36+,37+,38-,39-,40+,41-,42-,43-,46-,47-,48+,50-,51+,52+,53+,54-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice. 2. Escin IIB enhances Mg(2+) absorption from the digestive tract in mice, in which the constitutive, but not the inducible, NO synthase plays an important role. 3. Escin IIB shows gastroprotection on ethanol-induced gastric mucosal lesions, whereas endogenous prostaglandins, NO, capsaicin-sensitive afferent neurons, and the sympathetic nervous system participate. |
| Targets | NO | NOS |
Escin IIB Dilution Calculator
Escin IIB Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.9081 mL | 4.5403 mL | 9.0807 mL | 18.1613 mL | 22.7017 mL |
| 5 mM | 0.1816 mL | 0.9081 mL | 1.8161 mL | 3.6323 mL | 4.5403 mL |
| 10 mM | 0.0908 mL | 0.454 mL | 0.9081 mL | 1.8161 mL | 2.2702 mL |
| 50 mM | 0.0182 mL | 0.0908 mL | 0.1816 mL | 0.3632 mL | 0.454 mL |
| 100 mM | 0.0091 mL | 0.0454 mL | 0.0908 mL | 0.1816 mL | 0.227 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Salvianolic acid F
Catalog No.:BCN2924
CAS No.:158732-59-3
- Aescin IIA
Catalog No.:BCN6551
CAS No.:158732-55-9
- 2-Naphthyl N-benzoylphenylalaninate
Catalog No.:BCC8583
CAS No.:15873-25-3
- Dihydrexidine hydrochloride
Catalog No.:BCC5681
CAS No.:158704-02-0
- Rimonabant hydrochloride
Catalog No.:BCC1898
CAS No.:158681-13-1
- Ombuin 3-glucoside
Catalog No.:BCN4055
CAS No.:158642-42-3
- Eclalbasaponin I
Catalog No.:BCN8244
CAS No.:158511-59-2
- Cnidioside B methyl ester
Catalog No.:BCN1707
CAS No.:158500-59-5
- Catalpalactone
Catalog No.:BCN1708
CAS No.:1585-68-8
- ω-Agatoxin TK
Catalog No.:BCC7489
CAS No.:158484-42-5
- BMS-983970
Catalog No.:BCC5509
CAS No.:1584713-87-0
- PSI
Catalog No.:BCC1124
CAS No.:158442-41-2
- GR 159897
Catalog No.:BCC7001
CAS No.:158848-32-9
- 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol
Catalog No.:BCN1550
CAS No.:158850-76-1
- Boc-ß-HoAla-OH
Catalog No.:BCC3224
CAS No.:158851-30-0
- 3Alaph-Tigloyloxypterokaurene L3
Catalog No.:BCN6787
CAS No.:1588516-87-3
- ent-17-Hydroxykaura-9(11),15-dien-19-oic acid
Catalog No.:BCN6788
CAS No.:1588516-88-4
- BET-BAY 002
Catalog No.:BCC5510
CAS No.:1588521-78-1
- GR 231118
Catalog No.:BCC7085
CAS No.:158859-98-4
- APC 366
Catalog No.:BCC7392
CAS No.:158921-85-8
- Boc-D-Tryptophanol
Catalog No.:BCC2698
CAS No.:158932-00-4
- Secoisolarisiresinol Diglucoside
Catalog No.:BCC9140
CAS No.:158932-33-3
- Wedelobatin A
Catalog No.:BCN6731
CAS No.:1589488-34-5
- Wedelobatin B
Catalog No.:BCN6730
CAS No.:1589488-35-6
Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals.[Pubmed:9353571]
Biol Pharm Bull. 1997 Oct;20(10):1092-5.
We investigated the effects of escins Ia, Ib, and IIb isolated from horse chestnut, the seeds of Aesculus hippocastanum L., and desacylescins I and II obtained by alkaline hydrolysis of escins on acute inflammation in animals (p.o.). Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibited the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibited that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibited the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibited the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Desacylescins I and II (200 mg/kg) showed no effect. With regard to the relationship between their chemical structures and activities, the acyl groups in escins were essential. Escins Ib, IIa, and IIb with either the 21-angeloyl group or the 2'-O-xylopyranosyl moiety showed more potent activities than escin Ia which had both the 21-tigloyl group and the 2'-O-glucopyranosyl moiety.
Enhancement by escins Ib and IIb of Mg(2+) absorption from digestive tract in mice: role of nitric oxide.[Pubmed:10650180]
Eur J Pharmacol. 2000 Jan 17;387(3):337-42.
The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The serum Mg(2+) levels were determined 30, 60, 120 and 180 min after administration of MgSO(4). Escins Ib and IIb (12.5 and 25 mg/kg) significantly increased the serum Mg(2+) by 10.0-27.3%, 30, 120 and 180 min after administration of the samples, and 30, 60, 120 and 180 min after administration of MgSO(4). Escins Ib and IIb (12.5 mg/kg) significantly decreased the Mg(2+) content in the small intestinal fluid in MgSO(4)-loaded mice, but did not increase the serum Mg(2+) levels in normal mice. The effects of escins Ib and IIb (12.5 mg/kg) on serum Mg(2+) levels were attenuated in a dose-related manner by the pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME, 3-20 mg/kg, i.p., an inhibitor of constitutive and inducible NO synthase), but not with D-NAME (10 mg/kg, i.p., the inactive enantiomer of L-NAME) or dexamethasone (0.05 and 0.5 mg/kg, s.c., an inhibitor of inducible NO synthase). The effect of L-NAME was reversed by L-arginine (600 mg/kg, i.p., a substrate of NO synthase), but not by D-arginine (900 mg/kg, i.p., the enantiomer of L-arginine). These results suggest that escins Ib and IIb enhance Mg(2+) absorption from the digestive tract in mice, in which the constitutive, but not the inducible, NO synthase plays an important role.
Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats.[Pubmed:10408252]
Eur J Pharmacol. 1999 May 28;373(1):63-70.
Effects of escins Ia, Ib, IIa, and IIb isolated from horse chestnuts on ethanol-induced gastric mucosal lesions and the roles of capsaicin-sensitive afferent neurons, endogenous nitric oxide (NO), sulfhydryls, prostaglandins, as well as gastric secretion and the sympathetic nervous system, were investigated in rats. Test samples were given orally to fasted rats 1 h before ethanol (1.5 ml/rat, p.o.) treatment or ligation of the pylorus. Escins Ia-IIb (10-50 mg/kg) potently inhibited ethanol-induced gastric mucosal lesions, whereas desacylescins I and II (50 mg/kg) showed no such effect. These active saponins (10 and 20 mg/kg) did not decrease the gastric secretion. The gastroprotections of escins Ia-IIb were attenuated by the pretreatment with capsaicin, N(G)-nitro-L-arginine methyl ester, and indomethacin, but not by N-ethylmaleimide. The effects of escins Ia-IIb were also attenuated in streptozotocin-induced diabetic rats, in which the activity of the sympathetic nervous system was abnormal. These results suggest that the gastroprotections of escins Ia-IIb on ethanol-induced gastric mucosal lesions are acid-independent, whereas endogenous prostaglandins, NO, capsaicin-sensitive afferent neurons, and the sympathetic nervous system participate.
