CimidahurinineCAS# 142542-89-0 |
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| Cas No. | 142542-89-0 | SDF | Download SDF |
| PubChem ID | 5315870 | Appearance | Oil |
| Formula | C14H20O8 | M.Wt | 316.3 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3R,4S,5S,6R)-2-[2-hydroxy-5-(2-hydroxyethyl)phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | ||
| SMILES | C1=CC(=C(C=C1CCO)OC2C(C(C(C(O2)CO)O)O)O)O | ||
| Standard InChIKey | QOGCASCQGJEYDO-RKQHYHRCSA-N | ||
| Standard InChI | InChI=1S/C14H20O8/c15-4-3-7-1-2-8(17)9(5-7)21-14-13(20)12(19)11(18)10(6-16)22-14/h1-2,5,10-20H,3-4,6H2/t10-,11-,12+,13-,14-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins. |
| Targets | ROS | Bcl-2/Bax |
Cimidahurinine Dilution Calculator
Cimidahurinine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1616 mL | 15.8078 mL | 31.6156 mL | 63.2311 mL | 79.0389 mL |
| 5 mM | 0.6323 mL | 3.1616 mL | 6.3231 mL | 12.6462 mL | 15.8078 mL |
| 10 mM | 0.3162 mL | 1.5808 mL | 3.1616 mL | 6.3231 mL | 7.9039 mL |
| 50 mM | 0.0632 mL | 0.3162 mL | 0.6323 mL | 1.2646 mL | 1.5808 mL |
| 100 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.6323 mL | 0.7904 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Triterpenoid glycoside from Cimicifuga racemosa.[Pubmed:16176901]
J Asian Nat Prod Res. 2005 Oct;7(5):695-9.
One new triterpene glycoside, cimiracemoside , and 14 known triterpene glycosides have been isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). On the basis of spectral and chemical evidence, the structure of the new compound was elucidated to be 12beta-acetoxycimigenol-3-O-beta-D-xylopranoside, and the known compounds were identified to be 25-acetylcimigenol xyloside, cimigenol-3-O-beta-D-xylopyranoside, acetin, 27-deoxyacetin, cimicifugoside H-1, 23-O-acetylshengmanol 3-O-beta-D-xylopranoside, foetidinol-3-O-beta-xyloside, cimicifugoside H-2, 25-O-methylcimigenol xyloside, 21-hydroxycimigenol-3-O-beta-D-xylopyranoside, 24-epi-7,8-didehydrocimigenol-3-xyloside, Cimidahurinine, cimidahurine and cimifugin. The compounds, , and showed weak antibacterial activities in the agar diffusion assay.
Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour.[Pubmed:24996318]
Food Chem. 2014 Dec 1;164:150-7.
A total of 11 phenolic compounds, as well as sucrose (12) and tryptophan (13), were isolated from cold-pressed Perilla frutescens var. arguta seed flour using column chromatography, and their chemical structures were identified as 3'-dehydroxyl-rosmarinic acid-3-o-glucoside (1), rosmarinic acid-3-o-glucoside (2), rosmarinic acid (3), rosmarinic acid methyl ester (4), luteolin (5), luteolin-5-o-glucoside (6), apigenin (7), caffeic acid (8), caffeic acid-3-o-glucoside (9), vanillic acid (10) and Cimidahurinine (11) using NMR and time-of-flight mass spectrometry. Of these components, compound 1 is novel, and this is the first report of compounds 10 and 11 in perilla seeds. HPLC quantification combined with antioxidant activity evaluation revealed that rosmarinic acid and rosmarinic acid-3-o-glucoside were the dominant phenolic antioxidants with strong antioxidant activities.
[Chemical constituents from fruits of Ligustrum lucidum].[Pubmed:20575386]
Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(7):861-4.
OBJECTIVE: To study the chemical constituents from the fruits of Ligustrum lucidum. METHOD: The chemical constituents from the ethanol extract of L. lucidum were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatographic methods. Their structures were identified on the basis of spectroscopic data and physico-chemical properties. RESULT: Twenty compounds were isolated and identified as oleanolic acid (1), crategolic acid (2), acetyl oleanolic acid (3), lupeol (4), betulin (5), dammarenediol-II (6), 3beta-acetyl-20, 25-epoxydammarane-24alpha-ol (7), 25-epoxydammarane-3beta, 24alpha-diol (8), dammar-24-ene-3beta-acetyl-20S-ol) (9), 20S, 24R-dammarane-25-ene-24-hydroperoxy-3beta, 20-diol (10), fouquierol (11), oliganthas A (12), dammarenediol II 3-O-palmitate (13), ocotillol II 3-O-palmitate (14), (E) -25-hydroperoxydammar-23-ene-3beta,20-diol (15), verbascoside (16), Cimidahurinine (17), 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (18), osmanthuside H (19), 2-(3,4-dihydroxyphenyl) ethanol (20). CONCLUSION: Compounds 4, 16,17, 19 were isolated from this plant for the first time, andcompounds 12-15 were isolated from this genus for the first time.
