Genkwanol BCAS# 142674-67-7 |
- Genkwanol C
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 142674-67-7 | SDF | Download SDF |
| PubChem ID | 15735849 | Appearance | Powder |
| Formula | C30H22O11 | M.Wt | 558.49 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1C(C(OC2=C1C(=O)C=C3C24C(C(O3)C5=CC=C(C=C5)O)(C(=O)C6=C(C=C(C=C6O4)O)O)O)C7=CC=C(C=C7)O)O | ||
| Standard InChIKey | JTLAASAWWOBQSW-WHLDAIKOSA-N | ||
| Standard InChI | InChI=1S/C30H22O11/c31-15-5-1-13(2-6-15)25-21(36)11-18-19(34)12-23-30(28(18)40-25)29(38,27(39-23)14-3-7-16(32)8-4-14)26(37)24-20(35)9-17(33)10-22(24)41-30/h1-10,12,21,25,27,31-33,35-36,38H,11H2/t21-,25+,27-,29+,30-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Genkwanol B shows potent in vitro antiviral activity against respiratory syncytial virus (RSV). |
| Targets | Antifection |
Genkwanol B Dilution Calculator
Genkwanol B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7905 mL | 8.9527 mL | 17.9054 mL | 35.8108 mL | 44.7636 mL |
| 5 mM | 0.3581 mL | 1.7905 mL | 3.5811 mL | 7.1622 mL | 8.9527 mL |
| 10 mM | 0.1791 mL | 0.8953 mL | 1.7905 mL | 3.5811 mL | 4.4764 mL |
| 50 mM | 0.0358 mL | 0.1791 mL | 0.3581 mL | 0.7162 mL | 0.8953 mL |
| 100 mM | 0.0179 mL | 0.0895 mL | 0.1791 mL | 0.3581 mL | 0.4476 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiviral biflavonoids from Radix Wikstroemiae (Liaogewanggen).[Pubmed:20565950]
Chin Med. 2010 Jun 21;5:23.
BACKGROUND: Radix Wikstroemiae is a common Chinese herbal medicine. The ethyl acetate fraction of the ethanolic extract of W. indica possesses potent in vitro antiviral activity against respiratory syncytial virus (RSV). This study aims to identify the antiviral components of the active fraction. METHODS: The active fraction of the Radix Wikstroemiae extract was isolated with chromatographic methods such as silica gel, Sephadex LH-20 and semi-preparative high performance liquid chromatography (HPLC) columns. The structures of the isolated compounds were determined based on spectroscopic analyses. The in vitro antiviral activity of the compounds against RSV was tested with the cytopathic effect (CPE) reduction assay and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. RESULTS: Four biflavonoids, namely neochamaejasmin B, Genkwanol B, genkwanol C and stelleranol, were isolated and characterized. Genkwanol B, genkwanol C and stelleranol, which are stereo isomers of spirobiflavonoids, showed potent anti-RSV activity whereas neochamaejasmin B did not. CONCLUSION: Neochamaejasmin B, Genkwanol B, genkwanol C and stelleranol were isolated from Radix Wikstroemiae and the complete absolute configurations of five chiral carbons in stelleranol were substantiated for the first time. Furthermore, the anti-RSV activity of Genkwanol B, genkwanol C and stelleranol was reported for the first time.
