4-Chlorophenylguanidine hydrochlorideUrokinase inhibitor, potent and specific CAS# 14279-91-5 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 14279-91-5 | SDF | Download SDF |
| PubChem ID | 6338670 | Appearance | Powder |
| Formula | C7H9ClN3+ | M.Wt | 170.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | (4-chlorophenyl)-(diaminomethylidene)azanium | ||
| SMILES | C1=CC(=CC=C1[NH+]=C(N)N)Cl | ||
| Standard InChIKey | ZSJNJAJDBNFVCA-UHFFFAOYSA-O | ||
| Standard InChI | InChI=1S/C7H8ClN3/c8-5-1-3-6(4-2-5)11-7(9)10/h1-4H,(H4,9,10,11)/p+1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and specific inhibitor of urokinase. |
4-Chlorophenylguanidine hydrochloride Dilution Calculator
4-Chlorophenylguanidine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.8617 mL | 29.3083 mL | 58.6166 mL | 117.2333 mL | 146.5416 mL |
| 5 mM | 1.1723 mL | 5.8617 mL | 11.7233 mL | 23.4467 mL | 29.3083 mL |
| 10 mM | 0.5862 mL | 2.9308 mL | 5.8617 mL | 11.7233 mL | 14.6542 mL |
| 50 mM | 0.1172 mL | 0.5862 mL | 1.1723 mL | 2.3447 mL | 2.9308 mL |
| 100 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.1723 mL | 1.4654 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].
Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.
4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively [1].
Reference:
[1]. Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.
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Urokinase inhibitor
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