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5,7-Dimethoxyluteolin

CAS# 90363-40-9

5,7-Dimethoxyluteolin

Catalog No. BCN8167----Order now to get a substantial discount!

Product Name & Size Price Stock
5,7-Dimethoxyluteolin : 5mg $207 In Stock
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Quality Control of 5,7-Dimethoxyluteolin

Number of papers citing our products

Chemical structure

5,7-Dimethoxyluteolin

3D structure

Chemical Properties of 5,7-Dimethoxyluteolin

Cas No. 90363-40-9 SDF Download SDF
PubChem ID 13964548 Appearance Powder
Formula C17H14O6 M.Wt 314.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-5,7-dimethoxychromen-4-one
SMILES COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)OC
Standard InChIKey NKGJZNRUAGQIRY-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H14O6/c1-21-10-6-15(22-2)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)12(19)5-9/h3-8,18-19H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,7-Dimethoxyluteolin

The herbs of Hovenia acerba

Biological Activity of 5,7-Dimethoxyluteolin

Description5,7-Dimethoxyluteolin is a natural product from Hovenia acerba.

Protocol of 5,7-Dimethoxyluteolin

Structure Identification
Journal of Gannan Medical University, 2012,32(4):495-6.

Synthesis of natural flavone:5-methoxy-luteolin[Reference: WebLink]

5,7-Dimethoxyluteolin is one of main flavones in Traditional Chinese Medicine Hovenia dulcis Thunb.
METHODS AND RESULTS:
Luteolin was obtained from the hydrolysis of rutin.5,7-dimethoxy-luteolin in total yield of 7.9% was synthesized by reaction of protection of hydroxyl group,etherification,and deprotection.The structures were confirmed by 1H NMR and 13C NMR.

5,7-Dimethoxyluteolin Dilution Calculator

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5,7-Dimethoxyluteolin Molarity Calculator

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Preparing Stock Solutions of 5,7-Dimethoxyluteolin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,7-Dimethoxyluteolin

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.[Pubmed: 20188172 ]

Pharmacol Res. 2010 Jun;61(6):519-24.

Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC(50)). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC(50) values of approximately 10 microM. Senkyunolide O and cryptotanshinone were COX-2 selective inhibitors with IC(50) values of 5 microM and 22 microM, respectively. Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC(50) values of most of these natural product ligands have not been reported previously.

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