Clausine DCAS# 142846-95-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 142846-95-5 | SDF | Download SDF |
PubChem ID | 3035740 | Appearance | Yellow powder |
Formula | C18H17NO2 | M.Wt | 279.34 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 1-hydroxy-4-(3-methylbut-2-enyl)-9H-carbazole-3-carbaldehyde | ||
SMILES | CC(=CCC1=C2C3=CC=CC=C3NC2=C(C=C1C=O)O)C | ||
Standard InChIKey | PNBKXALRNLUCJB-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C18H17NO2/c1-11(2)7-8-13-12(10-20)9-16(21)18-17(13)14-5-3-4-6-15(14)19-18/h3-7,9-10,19,21H,8H2,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2. |
Targets | PAFR |
Clausine D Dilution Calculator
Clausine D Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.5799 mL | 17.8993 mL | 35.7987 mL | 71.5973 mL | 89.4967 mL |
5 mM | 0.716 mL | 3.5799 mL | 7.1597 mL | 14.3195 mL | 17.8993 mL |
10 mM | 0.358 mL | 1.7899 mL | 3.5799 mL | 7.1597 mL | 8.9497 mL |
50 mM | 0.0716 mL | 0.358 mL | 0.716 mL | 1.4319 mL | 1.7899 mL |
100 mM | 0.0358 mL | 0.179 mL | 0.358 mL | 0.716 mL | 0.895 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- L-Sulforaphane
Catalog No.:BCN8449
CAS No.:142825-10-3
- Clinopodiside A
Catalog No.:BCN2621
CAS No.:142809-89-0
- Preapiodionene
Catalog No.:BCN1854
CAS No.:142808-39-7
- Apiodionene
Catalog No.:BCN1829
CAS No.:142808-38-6
- DPN
Catalog No.:BCC7088
CAS No.:1428-67-7
- 5,7-Dimethoxyluteolin
Catalog No.:BCN8167
CAS No.:90363-40-9
- Silybin B
Catalog No.:BCN7898
CAS No.:142797-34-0
- 4-Chlorophenylguanidine hydrochloride
Catalog No.:BCC2382
CAS No.:14279-91-5
- IWP-L6
Catalog No.:BCC5101
CAS No.:1427782-89-5
- Domoic acid
Catalog No.:BCC6586
CAS No.:14277-97-5
- 12-Hydroxysapriparaquinone
Catalog No.:BCN3216
CAS No.:142763-37-9
- Anemarsaponin BIII
Catalog No.:BCN2898
CAS No.:142759-74-8
- N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Catalog No.:BCC6762
CAS No.:142867-52-5
- Toddacoumaquinone
Catalog No.:BCN3640
CAS No.:142878-03-3
- U 73343
Catalog No.:BCC8091
CAS No.:142878-12-4
- GM 6001
Catalog No.:BCC2119
CAS No.:142880-36-2
- 1-O-Ethylpiptocarphin F
Catalog No.:BCN6448
CAS No.:142891-12-1
- 8alpha-Methacryloyloxy-13-ethoxyvernojalcanolide
Catalog No.:BCN7445
CAS No.:142891-14-3
- Petunidin chloride
Catalog No.:BCN3018
CAS No.:1429-30-7
- OXF BD 02
Catalog No.:BCC5598
CAS No.:1429129-68-9
- Mutant IDH1 inhibitor
Catalog No.:BCC4144
CAS No.:1429180-08-4
- Triptoquinone B
Catalog No.:BCN6238
CAS No.:142937-50-6
- Triptoquinone A
Catalog No.:BCN6781
CAS No.:142950-86-5
- HPOB
Catalog No.:BCC5574
CAS No.:1429651-50-2
Antiplatelet effects of clausine-D isolated from Clausena excavata.[Pubmed:7918571]
Biochim Biophys Acta. 1994 Sep 28;1201(1):1-6.
Clausine-D inhibited concentration-dependently the aggregation and release reaction of washed rabbit platelets induced by arachidonic acid and collagen, without affecting those induced by U46619, PAF and thrombin. The IC50 values of clausine-D on arachidonic acid- and collagen-induced platelet aggregation were calculated to be 9.0 +/- 1.1 and 58.9 +/- 0.9 microM, respectively. Thromboxane B2 and prostaglandin D2 formation in platelets caused by arachidonic acid were also suppressed. Clausine-D inhibited increased intracellular concentration of calcium in platelets caused by arachidonic acid and collagen, and also abolished the generation of inositol monophosphate caused by arachidonic acid, but not that by collagen, U46619, PAF and thrombin. In human citrated platelet-rich plasma, clausine-D inhibited the secondary phase, but not the primary phase, of aggregation induced by epinephrine and ADP. These results indicate that the antiplatelet effect of clausine-D is due to inhibition of the formation of thromboxane A2.
Clausine-D and -F, two new 4-prenylcarbazole alkaloids from Clausena excavata.[Pubmed:1525939]
Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1069-71.
Two new 4-prenylcarbazole alkaloids, clausine-D (1) and -F (3) were isolated from the stem bark of Clausena excavata. Their structures were elucidated by spectral methods. Both of clausine-D (1) and -F (3) showed significant antiplatelet aggregation activity.