1-(2-Chloroacetyl)pyrrolidine-2-carbonitrileCAS# 207557-30-5 |
Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 207557-30-5 | SDF | Download SDF |
| PubChem ID | 15480185 | Appearance | Powder |
| Formula | C7H9ClN2O | M.Wt | 172.61 |
| Type of Compound | Impurities | Storage | Desiccate at -20°C |
| Synonyms | 274901-37-0 | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | ||
| SMILES | C1CC(N(C1)C(=O)CCl)C#N | ||
| Standard InChIKey | YCWRPKBYQZOLCD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C7H9ClN2O/c8-4-7(11)10-3-1-2-6(10)5-9/h6H,1-4H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile Dilution Calculator
1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.7934 mL | 28.967 mL | 57.9341 mL | 115.8681 mL | 144.8352 mL |
| 5 mM | 1.1587 mL | 5.7934 mL | 11.5868 mL | 23.1736 mL | 28.967 mL |
| 10 mM | 0.5793 mL | 2.8967 mL | 5.7934 mL | 11.5868 mL | 14.4835 mL |
| 50 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.3174 mL | 2.8967 mL |
| 100 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.1587 mL | 1.4484 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors.[Pubmed:18941490]
Beilstein J Org Chem. 2008;4:20.
An alternative and practical synthesis of (S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into the carbonitrile via the corresponding amide intermediate. The synthesized pyrrolidine derivative was utilized to prepare DPP-IV inhibitor Vildagliptin.
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