Dendroaspis polylepis
Dendroaspis polylepis
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Natural products/compounds from Dendroaspis polylepis
- Cat.No. Product Name CAS Number COA
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BCN9078
Sodium taurocholate145-42-6
Instructions
Mambalgins, the Venom-origin Peptides as a Potentially Novel Group of Analgesics: Mini Review.[Pubmed: 29268691]
Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-sensing ion channels (ASICs) are being attributed to an increasingly larger significance in pain aetiology. Over the last few years, the mechanism of ASICs action, influence of their antagonists/agonists and clinical applications have been well described. However, the importance of this protein is significantly larger, not only from the perspective of pain management, but also in psychiatry of addiction or fear. Recently discovered peptides from three-finger toxin group, called mambalgins (isolated from Dendroaspis polylepis polylepsis) exhibit potent analgesic mechanisms of action on ASICs in animal model.
Astakines in arthropods-phylogeny and gene structure.[Pubmed: 29154857]
Astakine1 was isolated as a hematopoietic cytokine in the freshwater crayfish Pacifastacus leniusculus. In this study we detect and compare 79 sequences in GenBank, which we consider to be possible astakine orthologs, among which eleven are crustacean, sixteen are chelicerate and 52 are from insect species. Available arthropod genomes are searched for astakines, and in conclusion all astakine sequences in the current study have a similar exon containing CCXX(X), thus potentially indicating that they are homologous genes with the structure of this exon highly conserved. Two motifs, RYS and YP(N), are also conserved among the arthropod astakines. A phylogenetic analysis reveals that astakine1 and astakine2 from P. leniusculus and Procambarus clarkii are distantly related, and may have been derived from a gene duplication occurring early in crustacean evolution. Moreover, a structural comparison using the Mamba intestinal toxin (MIT1) from Dendroaspis polylepis as template indicates that the overall folds are similar in all crustacean astakines investigated.
