10-Gingerol, fresh ginger extract, inhibits the production of nitric oxide, IL-1β, IL-6 and TNF-α as well as their mRNA levels in LPS-activated BV2 microglia,exhibits a significant anti-neuroinflammatory capacity.[1]
10-Gingerol improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.[2]
10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity, suggests that it could be a potential therapeutic agent for the prevention and treatment of breast cancer.[3]
10-Gingerol has ameliorative effect on drug induced hepatotoxicity in albino rats.[4]
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[1] Ho S C, Chang K S, Lin C C. Food Chem, 2013, 141(3):3183-91.
[2] Sadakane C, Muto S, Nakagawa K, et al. Biochem Bioph Res Co, 2011, 412(3):506-11.
[3] Joo J H, Hong S S, Cho Y R, et al. Oncol Rep, 2016, 35(2):779-84.
[4] Saleh I, Alqasoumi. J Med Plants Res, 2012, 6(9): 1548-55.
[5] Lee S, Khoo C, Halstead C W, et al. J Aoac Int, 2007, 90(5):1219-26.
