A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-S position.
InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1
20(S)-Protopanaxadiol may inhibit the proliferation of Siha cells,and its mechanism may be related to up-regulating the expressions of p53, p21, and autophagy related gene Beclin 1and MAP1-LC3, and down-regulating the expression of cyclin-E.[1,2]
20 (S)-Protopanaxdiol may induce the apoptosis of PC3 cells, and its mechanism may be related to the down-regulation of Bcl-2 protein and the up-regulation of γH2Ax protein expression.[3]
20(S)-Protopanaxdiol may induce the apoptosis of Siha cells,and its mechanism may be related to the up-regulation of bax expression, and the up-regulation and activition of caspase family.[4,5]
20(S)-Protopanaxdiol saponins has protective effects on acute myocardial ischemia including improving heart function, decreasing cardiac oxygen consumption and increasing myocardial blood flow, etc.[6]
English website: (20S)-Protopanaxdiol
Japanese website: (20S)-Protopanaxdiol
Chinese website: (20S)-Protopanaxdiol
[1]Yu-Ming L U, Zhao L J, Wang H B, et al. Journal of Jilin University, 2013, 39(05):909-12.
[2] Duo X U, Zhao L J, Cheng H, et al. Journal of Jilin University, 2010, 36(6):1055-8.
[3] Cheng H, Zhao L J, Lu Y M, et al.Journal of Jilin University Medicine Edition, 2012, 38(3):482-5.
[4]ZhaoLJ, Duo XU, Liang Z W, et al. Journal of Jilin University Medicine Edition, 2010, 36(2):345-8.
[5] Zhao L J, Duo X U, Hong C, et al.Journal of Jilin University Medicine Edition, 2011, 37(1):26-9.
[6] Liu S, Sui D, Yu X, et al. Zhongguo Yao Xue Za Zhi, 2001, 36(1):25-9
[7] Yin S, Wu H, Xu F, et al. Acta Acad Med Militaris Tertiae, 2010, 32(7):658-60.
