Asperosaponin VI (ASA VI) is a kind of saponin in the medicinal herb Dipsacus asper Wall which has long been used as an antiosteoporosis drug, exhibits a significant induction of proliferation, differentiation and mineralization in MC3T3-E1 and primary osteoblastic cells, it may induce osteoblast maturation and differentiation, and then increase bone formation via increasing BMP-2 synthesis, and activating p38 and ERK1/2.[1]
Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall, plays protective roles on acute myocardial infarction in rats.[2]
Asperosaponin VI has protective effect against hypoxia-induced cardiomyocytes apoptosis probably by activating the PI3K/Akt and CREB pathways.[3]

English website: Asperosaponin VI
Japanese website: Asperosaponin VI
Chinese website: Asperosaponin VI

[1] Yinbo Niu †, Yuhua Li †, Huang H, et al. Phytothe Res , 2011, 25(11):1700-6.
[2] Li C, Liu Z J, Li G, et al. Eur J Pharmacol, 2010, 217(Pt 23):4123-31.
[3] Li C, Tian J, Li G, et al. Eur J Pharmacol, 2010, 649(1-3):100-7.
[4] Shan X, Wang J, Wu A. China Pharmacist, 2013, 16(03):388-90.