A 4'-methoxyisoflavone that is formononetin attached to a β-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1
Ononin, an isoflavonoid, was isolated from the soils of cultivated areas associated with the perennial weed,Pluchea lanceolata, aqueous solutions of this compound can significantly inhibit root and shoot growth of mustard at 1×10(-4) M, 5×10(-4) M, and 1×10(-3)M. [1]
Ononin has weak DPPH·free radical and the superoxide anion free radical scavenging capacity.[2]
Ononin, from Astragalus membranaceus, has an effect on the expression of HIF-1 in a concentration-dependent manner, low concentration could elevate the expression of HIF-1 while high concentration down-regulated the expression; the study provide reference for the anti-tumor effect of A. membranaceus and therapeutic effect of it for other disease.[3]
[1] Inderjit, Dakshini K M M. J Chem Ecol, 1992, 18(5):713-8.
[2] Yang H, Han K, Wan X C, et al. J Anhui Agricul Universit, 2011, 38(2):151-5.
[3] Liang L J, Zhao K J, Dong T X, et al. China Pharm, 2010(47):4422-4.
[4] Zhou Q, Ying L I, Dai Y P, et al. Chinese Trad Patent Med, 2014, 36(8):1674-7.
