InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
Costunolide, a sesquiterpene lactone isolated from the root of Saussurea lappa Clarke, has a variety of biological activities, including anti-carcinogenic and anti-fungal activities,
it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1 in LPS-stimulated RAW 264.7 cells. [1]
Costunolide induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release,which is one mechanism of the anticancer effect of costunolide. [2]
Costunolide has antipyretic and anti-inflammatory activities, intraplantar injection of costunolide also reduced the paw oedema, myeloperoxidase. [3]
Costunolide(20mg/kg bw) possesses normo-glycemic and hypolipidemic activity and hence it could be used as a drug for treating diabetes. [4]
Costunolide can reduce the viability and arrest cell cycling at mitosis in hepatoma cells, also enhance the killing effect of radiotherapy against human HCC cells.[5]
English website: Costunolide
Japanese website: Costunolide
Chinese website: Costunolide
[1] Jong Soon Kang, Yeo Dae Yoon, Ki Hoon Lee,et al. Biochem Bioph Res Co, 2004, 313(1):171-177.
[2] Lee M G, Lee K T, Chi S G, et al. Biol Pharm Bull, 2001, 24(3):303-6.
[3] Kassuya C A L, Cremoneze A, Barros L F L, et al. J Ethnopharmacol, 2009, 124(3):369-376.
[4] Eliza J, Daisy P, Ignacimuthu S, et al. J Ethnopharmacol, 2009, 179(2–3):329-334.
[5] Liu C Y, Chang H S, Chen I S, et al. Radiat Oncol, 2011, 6(1):1-8.
[6] Dong S, Liu Y T, Peng J B, et al. Benthamscience Com, 2011, 2(1):74-78.
