A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
Wogonin is one major constituent of Scutellaria baicalensis, possesses potent anticancer activities , the activities are largely due to their abilities to scavenge oxidative radicals, to attenuate NF-kappaB activity, to inhibit several genes important for regulation of the cell cycle, to suppress COX-2 gene expression and to prevent viral infections. [1]
Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and.endonuclease, induction of bax protein and suppression of Mcl-1 protein were detected in the process.[2]
Wogonin, baicalin, and baicalein are three major components of Scutellaria, they have anti-inflammatory activity against carrageenan-induced paw edema in rats, the baicalin exhibits the greatest inhibition activity.[3]
Wogonin can suppress the VEGF-stimulated migration and tube formation of human umbilical vein endothelial cells (HUVECs), also restrain VEGF-induced tyrosine phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), strongly suggests that wogonin might be a promising antitumor drug.[4]
Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax.[5]
[1] Min L W. New therapeutic aspects of flavones: Cancer Treatment Reviews, 2009, 35(35):57-68.
[2] Lee W R, Shen S C, Lin H Y, et al. Biochem Pharmacol, 2002, 63(2):225-36.
[3] Chun-ChingLin, Den-EnShieh. Am J Chinese Med, 1996, 24(1):31-6.
[4] Na L, Ying G, Yun L, et al. Life Sci, 2008, 82(17-18):956-63.
[5] Zhang M, Liu L P, Chen Y, et al. Life Sci, 2013, 92(1):55-62.
[6] Lin D, Liang W. China Pharmacist, 2009, 12(08):1044-6.
