Shanzhiside methylester

Catalog No.	BCN4187
CAS RN	64421-28-9
Molecular Weight	406.4
Molecular Formula	C17H26O11
Database	[PubChem]:382163529 [ChEBI]: [PCIDB]:10687

Definition

Standard InChI

InChI=1S/C17H26O11/c1-17(24)3-7(19)9-6(14(23)25-2)5-26-15(10(9)17)28-16-13(22)12(21)11(20)8(4-18)27-16/h5,7-13,15-16,18-22,24H,3-4H2,1-2H3/t7-,8-,9?,10?,11-,12+,13-,15+,16+,17+/m1/s1

Biological Activity

Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata , reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling; stimulation of the endogenous β-endorphin expression may be a novel and effective strategy for the discovery and development of analgesics for the long-term treatment of chronic pain. [1]

Product information

English website: Shanzhiside methylester
Japanese website: Shanzhiside methylester
Chinese website: Shanzhiside methylester

References

[1] Fan H, Li T F, Gong N, et al. Neuropharmacol, 2015, 101:98-109.
[2] Xi H E, Mao X, Fan P C, et al. Chinese J Exp Trad Med Formulae. 2010, 16(07):50-2