InChI=1S/C25H28O4/c1-15(2)5-9-19-20(13-17-11-12-25(3,4)29-24(17)23(19)27)21-10-7-16-6-8-18(26)14-22(16)28-21/h5-6,8,11-14,21,26-27H,7,9-10H2,1-4H3/t21-/m0/s1
Kazinol B, an isoprenylated flavan, inhibits the NO synthesis with an IC50 of 21.6 μM, has inhibition of nitric oxide production on LPS-activated macrophages.[1]
Kazinol B improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes, it might be a therapeutic candidate for diabetes mellitus.[2]
Kazinol B has inhibiion of SOCE, is probably attributable to a break in the Ca 2+ driven force of mitochondria.[3]
[1] Ryu J H, Ahn H, Lee H J. Fitoterapia, 2003, 74(4):350-4.
[2] Lee H, Hua L, Ji H J, et al. Fitoterapia, 2016, 112:90-96.
[3] Wang J P, Hsu M F, Ko H H, et al. N-S ArchPharmacol, 2004, 370(6):500-9.
