Advances have been made in the immunochemical biology of natural products tumors
Natural killer (NK) cells are an important immune cell Group to monitor the early development of tumor, and the interaction between the activated receptor NKG2D (natural-killer Group 2 member D) on the cell surface and the ligand NKG2D on the tumor cell surface plays an important role in the process of tumor immune monitoring by NK cells. Down-regulation or deletion of the expression of NKG2D ligands will result in weakened immunogenicity of tumor cells, thereby escaping the recognition and killing effect of NK cells. Therefore, activating the expression of NKG2D ligands on the surface of tumor cell membrane is an effective strategy to enhance the immune monitoring and clearance of NK cells.
Kunming institute of botany, Chinese Academy of Sciences, plant chemistry and state key laboratory of plant resources sustainable utilization in western natural products of pharmacology and drug discovery team furien team and important groups of plant chemistry and functional team, puno among, tenzin team through extensive close cooperation, screening from natural products won a series of regulation NKG2D ligands on the surface of tumor cell membrane antipodal - alkanes kauri two terpenoids. Chemical biology and molecular biology study found Parvifoline AA (PAA) through targeted peroxidase I and II (Peroxiredoxins I/II, Prxs - I/II) lead to active Oxygen levels in the cell (Reactive Oxygen Species, ROS) rise, and activate cells regulate protein kinase activity of ERK, which significantly increases the expression of NKG2D ligands, liver cell membrane surface, in turn, activate the body's immune activity of NK cells, Promote the immune killing and elimination of NK cells to liver cancer cells in vivo and in vitro. The results not only revealed the important regulatory role of prx-i /II in NK cell-mediated liver tumor immunity, but also suggested that khusane-type diterpenoid PAA, as a sensitizer for NK cell carcinoma immunotherapy, has important drug development potential and application prospect. This study provides a potential important molecular target and drug precursor for NK cell-based tumor immunotherapy.
Research results with "Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell - Mediated Cytolysis by Targeting Peroxiredoxin" title, published online in the Cell ZiKan Cell Chemical Biology. Dr Zhu huifang and Dr Wang bin are the co-authors of the paper, while Dr Li yan and Dr Puno bhumadanzun are the co-corresponding authors. The research was supported by the national natural science foundation of China, the service project of the kunming institute of botany, the 100 people program of the Chinese academy of sciences, and yunnan province's high-end science and technology talents.
