Azurocidin (AZU1), ProteinCatalog# BCP33565 |
| Product Name | Azurocidin (AZU1), Protein | ||
| Full Product Name | Azurocidin, Human Neutrophil (Cationic protein 37) | ||
| Product Synonym Names | Cationic antimicrobial protein CAP37; Heparin-binding protein | ||
| Product Gene Name | AZU1 protein | ||
| Research Use Only | For Research Use Only. Not for use in diagnostic procedures. | ||
| OMIM | 162815 | ||
| 3D Structure | ModBase 3D Structure for P20160 | ||
| Host | Human Neutrophil. Prepared from whole blood shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. | ||
| Purity/Purification | >=95% | ||
| Form/Format | Salt-free lyophilized solid.Appearance: Lyophilized | ||
| Solubility/Reconstitution Instructions | Use deionized water | ||
| Handling | Centrifuge the vial prior to opening. | ||
| Preparation and Storage | At -20 degree CShelf Life: 12 months | ||
| Other Notes | Small volumes of AZU1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. | ||
| Related Product Information for AZU1 protein | Background: The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin, however, lacks enzymatic activity. It is an antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions. | ||
| Product Categories/Family for AZU1 protein | Proteins and Enzymes; Native Proteins Proteins and Enzymes; Proteins and Enzymes (A-Z) | ||
| Applications Tested/Suitable for AZU1 protein | SDS-PAGE | ||
| NCBI GI # | 11342670 | ||
| NCBI GeneID | 566 | ||
| NCBI Accession # | NP_001691.1 | ||
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