Benserazide HClCAS# 14919-77-8 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 14919-77-8 | SDF | Download SDF |
| PubChem ID | 26964 | Appearance | Powder |
| Formula | C10H16ClN3O5 | M.Wt | 293.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Serazide; Ro 4-4602 | ||
| Solubility | DMSO : 100 mg/mL (340.48 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (170.24 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide;hydrochloride | ||
| SMILES | [H+].[Cl-].NC(CO)C(=O)NNCc1ccc(O)c(O)c1O | ||
| Standard InChIKey | ULFCBIUXQQYDEI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Benserazide Hydrochloride is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
Target: DOPA decarboxylase
Benserazide is commonly used for Parkinson's disease in combination with L-DOPA as a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. Administration of 5, 10 and 50 mg/kg benserazide to 6-OHDA-lesioned rats showed an identical increase in exogenous L-DOPA-derived extracellular DA levels, the time to reach the peak DA levels were significantly prolonged by benserazide dose-dependently. The AADC activity in the denervated striatal tissues showed a significant decrease by 10 mg/kg and 50 mg/kg benserazide. These results suggest that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA [1]. References: | |||||
Benserazide HCl Dilution Calculator
Benserazide HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4048 mL | 17.0242 mL | 34.0483 mL | 68.0967 mL | 85.1209 mL |
| 5 mM | 0.681 mL | 3.4048 mL | 6.8097 mL | 13.6193 mL | 17.0242 mL |
| 10 mM | 0.3405 mL | 1.7024 mL | 3.4048 mL | 6.8097 mL | 8.5121 mL |
| 50 mM | 0.0681 mL | 0.3405 mL | 0.681 mL | 1.3619 mL | 1.7024 mL |
| 100 mM | 0.034 mL | 0.1702 mL | 0.3405 mL | 0.681 mL | 0.8512 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Benserazide HCl
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Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC).
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