FulvineCAS# 6029-87-4 |
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| Cas No. | 6029-87-4 | SDF | Download SDF |
| PubChem ID | 442726 | Appearance | Powder |
| Formula | C16H23NO5 | M.Wt | 309.36 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C(=O)OCC2=CCN3C2C(CC3)OC(=O)C(C1(C)O)C | ||
| Standard InChIKey | PSUFRPOAICRSTC-ZLGRWFNRSA-N | ||
| Standard InChI | InChI=1S/C16H23NO5/c1-9-14(18)21-8-11-4-6-17-7-5-12(13(11)17)22-15(19)10(2)16(9,3)20/h4,9-10,12-13,20H,5-8H2,1-3H3/t9-,10+,12-,13-,16+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Fulvine is a hepatotoxic pyrrolizidine alkaloid. 2. An aqueous solution of Fulvine can produce an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight. |
Fulvine Dilution Calculator
Fulvine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2325 mL | 16.1624 mL | 32.3248 mL | 64.6496 mL | 80.812 mL |
| 5 mM | 0.6465 mL | 3.2325 mL | 6.465 mL | 12.9299 mL | 16.1624 mL |
| 10 mM | 0.3232 mL | 1.6162 mL | 3.2325 mL | 6.465 mL | 8.0812 mL |
| 50 mM | 0.0646 mL | 0.3232 mL | 0.6465 mL | 1.293 mL | 1.6162 mL |
| 100 mM | 0.0323 mL | 0.1616 mL | 0.3232 mL | 0.6465 mL | 0.8081 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxicity of the pyrrolizidine alkaloid fulvine to pancreatic acinar cells in the rat. Light microscopic, histochemical and ultrastructural studies.[Pubmed:1010013]
Exp Pathol (Jena). 1976;12(6):329-35.
Veno-occlusive disease of the liver is caused by the hepatotoxic pyrrolizidine alkaloid Fulvine which is found in the plant Crotolaria fulva. Histological, histochemical and electronmicroscopic studies carried out in Wistar rats showed that an aqueous solution of Fulvine produced an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.
Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols.[Pubmed:6426098]
Toxicol Lett. 1984 May;21(2):185-9.
Arylthiols - in contrast to n-alkylthiols, cysteine and reduced glutathione--dehydrogenated monocrotaline, Fulvine, their N-oxides and retronecine to activated pyrrole derivatives. All thiols used failed to dehydrogenate N-methyl derivatives of monocrotaline and Fulvine.
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