Midkine protein (MDK), Active ProteinCatalog# BCP35799 |
| Product Name | Midkine protein (MDK), Active Protein | ||
| Full Product Name | Recombinant Human Midkine protein (MDK) (Active) | ||
| Product Synonym Names | MK; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein | ||
| Product Gene Name | MDK active protein | ||
| Product Synonym Gene Name | MK1; NEGF2 | ||
| Research Use Only | For Research Use Only. Not for use in diagnostic procedures. | ||
| Sequence Positions | 21-143aa | ||
| Sequence | VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD | ||
| OMIM | M69148 mRNA | ||
| 3D Structure | ModBase 3D Structure for P21741 | ||
| Host | E Coli | ||
| Purity/Purification | >=97% as determined by SDS-PAGE and HPLC. (lot specific) | ||
| Form/Format | Lyophilized | ||
| Species | Homo sapiens (Human) | ||
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml. | ||
| Storage Buffer | 0.2 um filtered PBS, pH7.4,lyophilized | ||
| Endotoxin | Less than 1.0 EU/ug as determined by LAL method. | ||
| Protein Note | Protein will be provided with aseptic processing and endotoxin removal. | ||
| Preparation and Storage | Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C. | ||
| ISO Certification | Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory. | ||
| Active Protein Note | Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system. | ||
| Other Notes | Small volumes of MDK active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. | ||
| Related Product Information for MDK active protein | Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}. | ||
| Product Categories/Family for MDK active protein | Biological Active Protein; Neuroscience | ||
| SDS-PAGE of MDK active protein | (Note: Representative image, actual molecular weight may vary depending on Tag type and expression host) | ||
| NCBI GI # | 59894796 | ||
| NCBI GeneID | 4192 | ||
| NCBI Accession # | NP_001012333.1 | ||
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