SOS1, Recombinant ProteinCatalog# BCP29913 |
| Product Name | SOS1, Recombinant Protein | ||
| Full Product Name | SOS1, 564-1049aa, Human, His-tag, Baculovirus | ||
| Product Synonym Names | Son of sevenless homolog 1; SOS1; GF1; GGF1; GINGF; HGF; NS4 | ||
| Product Gene Name | SOS1 recombinant protein | ||
| Research Use Only | For Research Use Only. Not for use in diagnostic procedures. | ||
| Sequence | ADPEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDAYL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN PKPLPRFPKK YSYPLKSPGV RPSNPRPGTH HHHHH | ||
| OMIM | L13857 mRNA | ||
| 3D Structure | ModBase 3D Structure for Q07889 | ||
| Host | Baculovirus | ||
| Purity/Purification | > 95% by SDS-PAGE | ||
| Form/Format | Liquid. In 20mM Tris-HCl (pH 7.5) containing 30% glycerol, 0.1M NaCl, 1mM DTT, 0.2mM MgCl2. | ||
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) (lot specific) | ||
| Antigen Species | Human | ||
| Tag Information | His-tag | ||
| Endotoxin Level | < 1.0 EU per 1ug of protein (determined by LAL method) | ||
| Preparation and Storage | Can be stored at 4 degree C short term (1-2 weeks).For long term storage, aliquot and store at -20 degree C or -70 degree C.Avoid repeated freezing and thawing cycles. | ||
| Other Notes | Small volumes of SOS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. | ||
| Related Product Information for SOS1 recombinant protein | SOS1, also known as son of sevenless homolog 1, is a Ras and Rac guanine nucleotide exchange factor. This protein is composed of several important domains. The CDC25 and REM domains provide the catalytic activity of SOS1 towards Ras and the histone fold DH/PH (Dbl homology and Pleckstrin homology) domains function, in tandem, to stimulate GTP/GDP exchange for Rac. Also, binding of GTP activates Ras proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). Recombinant human SOS1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. | ||
| Product Categories/Family for SOS1 recombinant protein | Signal Transduction | ||
| Applications Tested/Suitable for SOS1 recombinant protein | SDS-PAGE | ||
| NCBI GI # | 15529996 | ||
| NCBI GeneID | 6654 | ||
| NCBI Accession # | NP_005624 | ||
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