T Cell Immunoreceptor With Ig and ITIM Domains (TIGIT), Recombinant ProteinCatalog# BCP31935 |
| Product Name | T Cell Immunoreceptor With Ig and ITIM Domains (TIGIT), Recombinant Protein | ||
| Full Product Name | Recombinant Human T Cell Immunoreceptor With Ig and ITIM Domains Protein | ||
| Product Synonym Names | T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9 | ||
| Product Gene Name | TIGIT recombinant protein | ||
| Research Use Only | For Research Use Only. Not for use in diagnostic procedures. | ||
| 3D Structure | ModBase 3D Structure for Q495A1 | ||
| Host | Human Cells | ||
| Purity/Purification | >95% as determined by reducing SDS-PAGE. | ||
| Form/Format | Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4. | ||
| Species | Human | ||
| Endotoxin | <1.0 EU per ug as determined by LAL test. | ||
| Fragment | Met22-Pro141 | ||
| Fusion Tag | C-6His | ||
| Activity | Measured by its ability to bind with human CD155-Fc in a functional ELISA. Measured by its ability to bind with mouse PVR-Fch in a functional ELISA. | ||
| Preparation and Storage | Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.Aliquots of reconstituted samples are stable at < -20 degree C for 3 months. | ||
| ISO Certification | Manufactured in an ISO 9001:2015 Certified Laboratory. | ||
| Other Notes | Small volumes of TIGIT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. | ||
| Related Product Information for TIGIT recombinant protein | Protein Construction: Recombinant Human T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His tag at the C-terminus.Background: T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1. | ||
| NCBI GI # | 256600228 | ||
| NCBI GeneID | 201633 | ||
| NCBI Accession # | NP_776160.2 | ||
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