ATM and ATR Kinase
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases which are part of the phosphatidylinositol 3' kinase-like kinase (PIKK) enzyme family.
Products for ATM and ATR Kinase
- Cat.No. Product Name Information/Activity
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BCC1389
AZ20
AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).
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BCC2475
KU 55933
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
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BCC5986
Mirin
Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex.
