ERK
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.
Products for ERK
- Cat.No. Product Name Information/Activity
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BCC2061
XMD17-109
XMD17-109 is a novel, specific ERK-5 inhibitor, with an IC50 of 162 nM.
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BCC3669
FR 180204
FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively.
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BCC2051
VX-11e
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
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BCC7745
TMCB
905105-89-7
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BCC2062
XMD8-92
XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.
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BCC6521
DEL-22379
DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM.
