MK2
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, or MK2) is a kinase belonging to the MAPKAPK family, a group of kinases activated by MAPK signaling. MK2 is activated by p38α and regulates the production of inflammatory cytokines, such as TNF-α .
Products for MK2
- Cat.No. Product Name Information/Activity
-
BCC6136
PF-3644022
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.
-
BCC7274
CMPD-1
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.
