Pim Kinase
Pim kinases are constitutively active serine/threonine kinases that promote growth factor-independent proliferation by phosphorylating, and thus inhibiting, a range of cellular proteins. They are serine/threonine kinases that control cell growth, differentiation and apoptosis.
Products for Pim Kinase
- Cat.No. Product Name Information/Activity
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BCC4924
Mitoxantrone HCl
Mitoxantrone dihydrochloride is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
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BCC2446
PIM-1 Inhibitor 2
Pim-1 kinase inhibitor
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BCC2447
TCS PIM-1 1
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM).
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BCC2233
SMI-4a
(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity.
