NUAK
NUAKs are AMPK-related kinases (ARKs). There are two known family members, NUAK1 (ARK5) and NUAK2 (SNARK), which are activated by liver kinase B1 (LKB1) and are important in cancer progression and metastasis, as well as carbohydrate metabolism.
Products for NUAK
- Cat.No. Product Name Information/Activity
-
BCC4010
HTH-01-015
HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
-
BCC4363
WZ4003
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
