H+,K+-ATPase
H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.
Products for H+,K+-ATPase
- Cat.No. Product Name Information/Activity
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BCC1058
Lansoprazole
Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid.
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BCC1254
Omeprazole
Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
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BCC2084
PF-03716556
PF 03716556 is a potent, and selective H+, K+-ATPase antagonist, with a pIC50 value of 6.009.
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BCC7154
SCH 28080
SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes. Antisecretory and cytoprotective activities.
